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Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study


Macfarlane, T.V.; Macfarlane, G.J.; Thakker, N.S.; Benhamou, S.; Bouchardy, C.; Ahrens, W.; Pohlabeln, H.; Lagiou, P.; Lagiou, A.; Castellsague, X. et al.
Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study // Annals of oncology, 23 (2012), 4; 1053-1060 doi:10.1093/annonc/mdr335 (međunarodna recenzija, članak, znanstveni)


Naslov
Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study

Autori
Macfarlane, T.V. ; Macfarlane, G.J. ; Thakker, N.S. ; Benhamou, S. ; Bouchardy, C. ; Ahrens, W. ; Pohlabeln, H. ; Lagiou, P. ; Lagiou, A. ; Castellsague, X. ; Richiardi, L. ; Talamini, R. ; Barzan, L. ; Kjaerheim, K. ; Canova, C. ; Simonato, L. ; Conway, D.I. ; McKinney, P.A. ; Thomson, P. ; Sloan, P. ; Znaor, Ariana ; Healy, C.M. ; McCartan, B.E. ; Marron, M. ; Brennan, P.

Izvornik
Annals of oncology (0923-7534) 23 (2012), 4; 1053-1060

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aspirin use; epidemiology; gastroesophageal reflux; medical history; medication use; upper

Sažetak
The study aimed to investigate the role of medical history (skin warts, Candida albicans, herpetic lesions, heartburn, regurgitation) and medication use (for heartburn ; for regurgitation ; aspirin) in the aetiology of upper aerodigestive tract (UADT) cancer. A multicentre (10 European countries) case–control study [Alcohol-Related CAncers and GEnetic susceptibility (ARCAGE) project]. There were 1779 cases of UADT cancer and 1993 controls. History of warts or C. albicans infection was associated with a reduced risk [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.68–0.94 and OR 0.73, 95% CI 0.60–0.89, respectively] but there was no association with herpetic lesions, heartburn, regurgitation or medication for related symptoms. Regurgitation was associated with an increased risk for cancer of the oesophagus (OR 1.47, 95% CI 0.98–2.21). Regular aspirin use was not associated with risk of UADT cancer overall but was associated with a reduced risk for cancer of oesophagus (OR 0.51, 95% CI 0.28–0.96), hypopharynx (OR 0.53, 95% CI 0.28–1.02) and larynx (OR 0.74, 95% CI 0.54–1.01). A history of some infections appears to be a marker for decreased risk of UADT cancer. The role of medical history and medication use varied by UADT subsites with aspirin use associated with a decreased risk of oesophageal cancer and suggestive of a decreased risk of hypopharyngeal and laryngeal cancers.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
005-1080315-0294 - Odrednice multiplih primarnih sijela raka u populaciji (Ariana Znaor, )

Ustanove
Hrvatski zavod za javno zdravstvo

Profili:

Avatar Url Ariana Znaor (autor)

Citiraj ovu publikaciju

Macfarlane, T.V.; Macfarlane, G.J.; Thakker, N.S.; Benhamou, S.; Bouchardy, C.; Ahrens, W.; Pohlabeln, H.; Lagiou, P.; Lagiou, A.; Castellsague, X. et al.
Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study // Annals of oncology, 23 (2012), 4; 1053-1060 doi:10.1093/annonc/mdr335 (međunarodna recenzija, članak, znanstveni)
Macfarlane, T., Macfarlane, G., Thakker, N., Benhamou, S., Bouchardy, C., Ahrens, W., Pohlabeln, H., Lagiou, P., Lagiou, A. & Castellsague, X. (2012) Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study. Annals of oncology, 23 (4), 1053-1060 doi:10.1093/annonc/mdr335.
@article{article, year = {2012}, pages = {1053-1060}, DOI = {10.1093/annonc/mdr335}, keywords = {aspirin use, epidemiology, gastroesophageal reflux, medical history, medication use, upper}, journal = {Annals of oncology}, doi = {10.1093/annonc/mdr335}, volume = {23}, number = {4}, issn = {0923-7534}, title = {Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe : the ARCAGE study}, keyword = {aspirin use, epidemiology, gastroesophageal reflux, medical history, medication use, upper} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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