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Pregled bibliografske jedinice broj: 563008

Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro


Horvat, Margareta; Uzelac, Lidija; Marjanović, Marko; Cindro, Nikola; Franković, Oliver; Mlinarić-Majerski, Kata; Kralj, Marijeta; Basarić, Nikola
Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro // Chemical biology & drug design, 79 (2012), 4; 497-506 doi:10.1111/j.1747-0285.2011.01305.x (međunarodna recenzija, članak, znanstveni)


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Naslov
Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro
(Evaluation of antiproliferative effect of N- (alkyladamantyl)phthalimides in vitro)

Autori
Horvat, Margareta ; Uzelac, Lidija ; Marjanović, Marko ; Cindro, Nikola ; Franković, Oliver ; Mlinarić-Majerski, Kata ; Kralj, Marijeta ; Basarić, Nikola

Izvornik
Chemical biology & drug design (1747-0277) 79 (2012), 4; 497-506

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
biological screening ; structure-based drug design ; adamantanes ; antiproliferation ; phthalimides

Sažetak
A series of (1-adamantyl)phthalimides, 1-4, and (2-adamantyl)phthalimides, 5-8, characterized by different chain length between the adamantyl and the phthalimide moiety were synthesized, as well as 1- and 2-adamantylphthalimides substituted by nitro 9, 10, and amino group 11, 12, and phthalimides bearing homoadamantyl 13 and protoadamantyl substituent 14 and 15. The compounds were tested for antiproliferative activity in vitro on a series of five human cancer lines: MCF-7 (breast carcinoma), SW 620 (colon carcinoma), HCT 116 (colon carcinoma), MOLT-4 (acute lymphoblastic leukemia), H 460 (lung carcinoma) and a non-tumor cell line HaCaT (human keratinocytes). All compounds except nitro derivatives 9 and 10 exhibited antiproliferative activity. The activity was generally better in the 2-adamantyl series 5- 8 and in the compounds having the longest alkyl spacers as in 4 and 8, or with an amino group as in 9 and 10. The most active compounds with the propylene spacer 4 and 8 showed the highest selectivity towards tumor cells. The activity was found to be due to a delay in the progress through the cell cycle at G1/S phase.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
02.05/25 - Fotokemija policikličkih molekula: od istraživanja mehanizama reakcije do novih lijekova i medicinskih primjena (Basarić, Nikola, HRZZ ) ( POIROT)
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( POIROT)
098-0982933-2911 - Kavezasti spojevi: ugradbene jedinice u molekularnim sustavima (Majerski, Kata, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Horvat, Margareta; Uzelac, Lidija; Marjanović, Marko; Cindro, Nikola; Franković, Oliver; Mlinarić-Majerski, Kata; Kralj, Marijeta; Basarić, Nikola
Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro // Chemical biology & drug design, 79 (2012), 4; 497-506 doi:10.1111/j.1747-0285.2011.01305.x (međunarodna recenzija, članak, znanstveni)
Horvat, M., Uzelac, L., Marjanović, M., Cindro, N., Franković, O., Mlinarić-Majerski, K., Kralj, M. & Basarić, N. (2012) Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro. Chemical biology & drug design, 79 (4), 497-506 doi:10.1111/j.1747-0285.2011.01305.x.
@article{article, year = {2012}, pages = {497-506}, DOI = {10.1111/j.1747-0285.2011.01305.x}, keywords = {biological screening, structure-based drug design, adamantanes, antiproliferation, phthalimides}, journal = {Chemical biology and drug design}, doi = {10.1111/j.1747-0285.2011.01305.x}, volume = {79}, number = {4}, issn = {1747-0277}, title = {Evaluation of antiproliferative effect of N-(alkyladamantyl)phthalimides in vitro}, keyword = {biological screening, structure-based drug design, adamantanes, antiproliferation, phthalimides} }
@article{article, year = {2012}, pages = {497-506}, DOI = {10.1111/j.1747-0285.2011.01305.x}, keywords = {biological screening, structure-based drug design, adamantanes, antiproliferation, phthalimides}, journal = {Chemical biology and drug design}, doi = {10.1111/j.1747-0285.2011.01305.x}, volume = {79}, number = {4}, issn = {1747-0277}, title = {Evaluation of antiproliferative effect of N- (alkyladamantyl)phthalimides in vitro}, keyword = {biological screening, structure-based drug design, adamantanes, antiproliferation, phthalimides} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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