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Analysis of HLA Class II Allele Frequencies on the Island of Hvar - Croatia


Kaštelan, Darko; Žunec, Renata; Grubić, Zorana; Kerhin, Vesna; Šuman, Ana; Čečuk, Esma; Martinović, Irena; Bakran, Maja; Janićijević, Branka; Rudan, Pavao; Kaštelan, Andrija
Analysis of HLA Class II Allele Frequencies on the Island of Hvar - Croatia // Abstracts of the 12th International Histocomaptibility Conference ; u: Human Immunology 47 (2008) (1/2) / Charron, Dominique (ur.).
Pariz: Elsevier, 1996. str. 141-141 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Analysis of HLA Class II Allele Frequencies on the Island of Hvar - Croatia

Autori
Kaštelan, Darko ; Žunec, Renata ; Grubić, Zorana ; Kerhin, Vesna ; Šuman, Ana ; Čečuk, Esma ; Martinović, Irena ; Bakran, Maja ; Janićijević, Branka ; Rudan, Pavao ; Kaštelan, Andrija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 12th International Histocomaptibility Conference ; u: Human Immunology 47 (2008) (1/2) / Charron, Dominique - Pariz : Elsevier, 1996, 141-141

Skup
International Histocomaptibility Conference (12 ; 1996)

Mjesto i datum
Pariz, Francuska, 09-12.06.1996

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HLA class II; island of Hvar; anthropology; population structure

Sažetak
The island of Hvar belongs to the group of Middle Dalmatian Islands, part of the territory of the Republic of Croatia. Geography, ethnohistory and demography of the island of Hvar indicate that analyses of genetic features needs to be based on west-east dichotomy. As part of the anthropology component of the 12th workshop we have studied 105 unrelated inhabitants of Hvar. The DRB1, DRB3, DRB4, DRB5, DQA1, DQB1 gene polymorphism was analysed by PCR-SSOP method using 12th Workshop primers and probes. On the basis of association data together with knowledge of haplotypes previously defined we were able to determine which DR-DQ haplotypes were probably carried by each individual. Thirty-one DRB1, 4 DRB3, 2 DRB5, / DQA1, 16 DQB1 alleles have been identified. Analysis of DRB1-DQA1-DQB1 haplotypes revealed a great diversity. Thirty-four and 38 distinct haplotypes have been identified on the east and west part of the island, respectively. Significant differences were observed between those two parts of island for 1.DRB1*0701 allele (p?0.001) 2.DQA1*0201 allele (p?0.01) and 3.DRB1*0101-DQA*0101-DQB1*0501 haplotype (p?0.05). Unusual haplotype DRB1*0101-DQA*0101-DQB1*0501 was found in 2 individuals from the west and in 3 individuals from the east while unusual haplotype DRB1*1501-DQA1*0102-DQB1*0604 was observed only on the western part. These data support the previously observed west-east dichotomy of the island of Hvar.

Izvorni jezik
Engleski

Znanstvena područja
Etnologija i antropologija

Napomena
DOI: 10.1016/0198-8859(96)85463-2

Časopis indeksira:


  • Scopus
  • MEDLINE