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Pregled bibliografske jedinice broj: 56170

The study of population structure based on the analysis of HLA-DRB1, DRB3, DRB4, DRB5, DQA1, DQB1 Polymorphisms (an example of the Island of Hvar, Croatia)


Kaštelan, Andrija; Grubić, Zorana; Žunec, Renata; Kerhin, Vesna; Kaštelan, Darko; Šuman, Ana; Martinović, Irena; Bakran, Maja; Janićijević, Branka; Jovanović, Veljko et al.
The study of population structure based on the analysis of HLA-DRB1, DRB3, DRB4, DRB5, DQA1, DQB1 Polymorphisms (an example of the Island of Hvar, Croatia) // Abstracts of the 12th International Histocomaptibility Conference ; u: Human Immunology 47 (1996) (1/2) / Charron, Dominique (ur.).
Pariz: Elsevier, 1996. str. 54-54 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
The study of population structure based on the analysis of HLA-DRB1, DRB3, DRB4, DRB5, DQA1, DQB1 Polymorphisms (an example of the Island of Hvar, Croatia)

Autori
Kaštelan, Andrija ; Grubić, Zorana ; Žunec, Renata ; Kerhin, Vesna ; Kaštelan, Darko ; Šuman, Ana ; Martinović, Irena ; Bakran, Maja ; Janićijević, Branka ; Jovanović, Veljko ; Smolej, Nina ; Rudan, Pavao

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 12th International Histocomaptibility Conference ; u: Human Immunology 47 (1996) (1/2) / Charron, Dominique - Pariz : Elsevier, 1996, 54-54

Skup
12th International Histocomaptibility Conference (12 ; 1996)

Mjesto i datum
Pariz, Francuska, 09-12.06.1996

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HLA polymorphisms; population structure; island of Hvar; anthropology; population genetics

Sažetak
Allele frequencies at the HLA-DRB1, DRB3, DRB4, DRB5, DQA1, DQB1 loci were determined in six rural populations of the island of Hvar, Croatia, using PCR methodology and non-radioactive oligonucleotide hybridisation. Allele frequencies, measures of genetic kinship (R matrix) and genetic distances (E2) were computed. The studied rural populations revealed isolation and clusterisation which coincides with the known ethnohistorical and socio-cultural data. The five studied groups formed two clusters (East-West) to which the sixth group (with highest Rii of 0.04036) joined later, thus indicating possible impact of historical immigrations from the mainland. Further on, genetic and geographic distances, as well as migrational kinship were utilised for quadratic assignment procedures, indicating high statistical significance for the both positive (genetic vs. geographic distances, r=0.6787) and negative (genetic distance vs. migrational kinship, r=-0.6109 ; geographic distances vs. migrational kinship, r=-0.5357) correlations. The possibilities and relevance of this kind of anthropological population structure analysis based on HLA polymorphisms is stressed.

Izvorni jezik
Engleski

Znanstvena područja
Etnologija i antropologija

Napomena
DOI: 10.1016/0198-8859(96)84979-2

Časopis indeksira:


  • Scopus
  • MEDLINE