engleski

DIAGNOSTIC VALUE OF URINE NGAL IN ACUTE PYELONEFRITIS OF CHILDREN

Background. Neutrophylgelatinase-associated lipocalin (NGAL) is a small protein expressed in renal tubules where it is a consirederably induced in ischemic or nephrotoxic injury. The aim of this study was to assess diagnostic value og urine NGAL as a biomarker of acute ascending urinary tract infection in children. Methods. We analyzed 52 children which were admitted to the Pedriatic Clinic. 33 of them had acute pyelonephrytis, while 19 who represented controls had cystitis or fever of the etiology. Besides routine laboratory analysis (CBC, CRP and urine analysis), urine culture, kidney ultasound and static scintigraphy were also done. Urine NGAL was measured using CMIA method (ARCHITECT i1000, ABBOT). We compared NGAL concentration in children with acute pyelonephrytis towards those from control group. Statistical calculation was performed using Mann-Whitney Rank Sum Test. Results. NGAL concentrations were significantly elevated in children with acute pyelonephritis in comparison with controls (median=119, 3 ng/ml vs 10, 2 ng/ml, p<0, 001). Conclusion. Since urine NGAL is fast test, easy to perform, and require noninvasive sample, it could be useful biomarker of acute pyelonephrytis in children.

Urine NGAL ; Biomarker ; Children ; Pyelonephrytis

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