NADPH and Iron may have an important role in attenuated mucosal defense in Helicobacter pylori infection? (CROSBI ID 179509)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Dovhanj, Jasna ; Kljaić, K. ; Smolić, Martina ; Švagelj, Dražen
engleski
NADPH and Iron may have an important role in attenuated mucosal defense in Helicobacter pylori infection?
Host intracellular iron has been recognized as an important cofactor in induction of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidative burst as antimicrobial defense mechanism. It is plausible that iron chelator directly inactivates NADPH oxidase by chelating the active site heme iron of flavocytochrome b558 thus blocking the transfer of electrons from NADPH to oxygen and its reduction to superoxide anion. Thus, altering the equilibrium of intracellular iron could influence the course of infection to the enhancement of the pathogen with regard to oxidative stress.
Free radicals; Helicobacter pylori; Iron; NADPH
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Podaci o izdanju
10
2010.
1309-1315
objavljeno
1389-5575
10.2174/138955710793564160
Povezanost rada
Kliničke medicinske znanosti