engleski

Plasma leptin in obesity related hypertension

Background and Purpose: It is well known that obesity is related to hypertension through several mechanisms, such as sympathetic overactivity and excess renal sodium reabsorption. Obesity and hypertensionmay also be linked by leptin, a peptide that is elevated in obese individuals. Leptin is an adipocyte derived hormone that acts in hypothalamus to regulate appetite, energy expenditure and sympathetic nervous system outflow, as well as in peripheral tissues, such as blood vessels and kidneys. The aim of our research was to determine plasma leptin in hypertensive and normotensive obese patients with the same body mass index (BMI) and show a possible difference between leptin levels in these two groups of patients. Materials and Methods: The research was carried out on 21 hypertensive and 19 normotensive patients (20 men and 20 women) with BMI in range 30–35 kg/m2, normal values of fasting plasma glucose, urea and creatinine. Leptin was determined using Elisa method. Results and Conclusion: The results showed that men had significantly higher waist to hip ratio (W/H). Plasma leptin was significantly higher in hypertensive women as well as in hypertensive men (p=0.03) in relation to normotensive patients. There was also significant difference in serum craetinine and creatinine clearance between normotensive and hypertensive women, although creatinine was within normal range. There was a significant difference in serum tryglicerides between men and women in general, where men had higher values (p=0.016). This confirmed that leptin correlates with hypertension in both men and women.

leptin; obesity

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