engleski

Effect of spinal and general anaesthesia on serum concentration of pro-inflammatory and anti- inflammatory cytokines

Background: Surgery induces release of neuroendocrine hormones, cytokines and acute phase proteins. The aim of this study was to assess the effect of spinal and general anaesthesia on serum concentration of pro-inflammatory and anti- inflammatory cytokines and cytokines which are secreted by Th1 helper lymphocytes. Methods: 30 patients with American Society of Anesthesiologists status I and II who were scheduled for TURP ( Transurethral Resection of the Prostata) were anesthetized in regional (spinal) or general anesthesia. peripheral venous blood samples were collected 2 hours before surgery on the first, third and fifth postoperative days. We measerud pro-inflammatory cytokines, anti-inflammatory cytokines and cytokines which are secreted by Th1 helper lymphocytes in order to establish differences in patients before and after surgery. Results:statistically significant differences (p=0.043) were found in serum levels of interleukin-2 (IL-2) between general and spinal anesthesia. The concentration of IL-2 was continously elevated in general anesthesia, but not in spinal anesthesia. Ther was also stotistically significant increase of interleukin- 6 (IL-6) in spinal (p=0.43) and general anesthesia (p=0.03) in comparison to preoperative value. Conclusion: surgery-related postoperative release of the pro-inflammatory cytokine IL-6 was increased in patients after spinal and general anesthesia. In our study, increased levels of the typical Th1 cytokine IL-2 were found in patients anesthetized by general anesthesia compared to spinal anesthesia. Serum concentrtions of other pro-inflammatory cytokines, anti-inflammatory cytokines which are secreted by Th1 helper lymphocytes showed no statistical difference before and after surgery under general and spinal anesthesia

spinal anesthesia ; general anesthesia ; interleukin-2 (IL-2) ; interleukin-6 (IL-6)

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