engleski

ACE I/D polymorphism in lung malignancy

Objective: Angiotensin converting enzyme (ACE) plays an important role in cardiovascular homeostasis and inflammation processes. Its plasma levels depend on the insertion/deletion (I/D) polymorphism so that homozygotes for the I allele have the lowest, and homozygotes for the D allele the highest plasma levels. It has been shown that ACE II genotype positively correlates with cell survival thus increasing malignancy. Moreover, it has been found that patients with lung cancer have decreased ACE plasma levels. We investigated whether ACE I/D polymorphism genotype distribution differs between patients with primary lung cancer and patients with lung malignancy as a second primary cancer. Methods: 201 patients with primary lung carcinoma as first malignancy and 107 patients with second primary lung carcinoma were included in this study. ACE I/D genotypes were determined by polymerase chain reaction. Results: Genotype distribution and allelic frequencies between patients with primary lung cancer and patients with second primary lung cancer were significantly different (ACE II genotype 16.4% vs. 29.0%, p=0.009 ; ACE I allele 41.0% vs. 51.9%, p=0.010). Conclusions: Results suggest that the II genotype and the I allele could be risk factors for developing second primary lung carcinoma.

ACE I/D polymorphism; lung cancer; second primary malignancy; cancer susceptibility; genetics

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