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Association of interleukin-6 and transforming growth factor-β1 gene polymorphisms with developmental hip dysplasia and severe adult hip osteoarthritis: a preliminary study


Kolundžić, Robert; Trkulja, Vladimir; Mikolaučić, Michele; Jovanić Kolundžić, Mirna; Kraljević Pavelić, Sandra; Pavelić, Krešimir
Association of interleukin-6 and transforming growth factor-β1 gene polymorphisms with developmental hip dysplasia and severe adult hip osteoarthritis: a preliminary study // Cytokine, 54 (2011), 2; 125-128 doi:10.1016/j.cyto.2011.02.004 (međunarodna recenzija, kratko priopcenje, znanstveni)


Naslov
Association of interleukin-6 and transforming growth factor-β1 gene polymorphisms with developmental hip dysplasia and severe adult hip osteoarthritis: a preliminary study

Autori
Kolundžić, Robert ; Trkulja, Vladimir ; Mikolaučić, Michele ; Jovanić Kolundžić, Mirna ; Kraljević Pavelić, Sandra ; Pavelić, Krešimir

Izvornik
Cytokine (1043-4666) 54 (2011), 2; 125-128

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
Interleukin-6 ; transforming growth factor-β1 ; gene polymorphisms ; developmental hip dysplasia ; hip ; osteoarthritis

Sažetak
Developmental hip dysplasia (DDH) greatly contributes to occurrence of severe hip osteoarthritis (OA) in adulthood, but the association between the two is not a perfect one. Both conditions are known to have a strong genetic component. Transforming growth factor β1 (TGF-β1) and interleukin-6 (IL-6) are two pro-inflammatory cytokines included in pathogenesis of OA, bone remodeling and development of bone and joint tissues. TGF-β1 gene has a polymorphic site in the signal sequence ((29)T→C) and "C allele carriage" is associated with higher circulating TGF-β1 levels. IL-6 gene has several polymorphic sites in the promoter region including -572T→C transition associated with higher circulating IL-6 levels. As a preliminary investigation on possible association between these polymorphisms and severe adult hip OA secondary to DDH, 28 consecutive patients and 20 healthy controls were genotyped at these loci. With adjustment for sex, "C allele carriage" in the TGF-β1 signal sequence and CC genotype ("transition homozygous") at locus -572 in the IL-6 promoter were each associated with severe OA secondary to DDH (OR=13.4, p=0.016 and OR=6.2, p=0.024, respectively). The combination of these genotypes was particularly strongly associated with the disease (OR=11.1, p<0.001). Data support feasibility of larger-scale studies on potential association between TGF-β1 signal sequence and IL-6 promoter polymorphisms and occurrence of DDH and (un)related severe OA.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0000000-3530 - Molekularna osnova aseptičke nestabilnosti totalne endoproteze zgloba kuka (Robert Kolundžić, )
108-1080233-0157 - Hrvatski registar endoproteza (Miroslav Smerdelj, )
335-0000000-3530 - Molekularna osnova aseptičke nestabilnosti totalne endoproteze zgloba kuka (Robert Kolundžić, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Sveučilište Libertas,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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