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NMR Spectroscopy for studying interactions of bioactive molecules


Novak, Predrag; Jednačak, Tomislav
NMR Spectroscopy for studying interactions of bioactive molecules // Physico-Chemical methods in Drug discovery / Mandić, Zoran (ur.).
Zagreb: IAPC, 2011. str. 1-62


Naslov
NMR Spectroscopy for studying interactions of bioactive molecules

Autori
Novak, Predrag ; Jednačak, Tomislav

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, ostalo

Knjiga
Physico-Chemical methods in Drug discovery

Urednik/ci
Mandić, Zoran

Izdavač
IAPC

Grad
Zagreb

Godina
2011

Raspon stranica
1-62

ISBN
978-953-56942-0-5

Ključne riječi
NMR techniques , drug discovery, macrolides, ribosomes, epitopes, drug design

Sažetak
One of the main prerequisites for a successful design of bioactive molecules and drugs is elucidation of three-dimensional structure of small molecular ligands, receptors and their complexes. Key steps in this process involve identification of structural elements and groups responsible for bioactivity. On the other hand, our ability to design novel drug candidates simply from high-resolution structures of biomolecules is still limited. A deeper understanding of molecular mechanisms and dynamics involved in the interaction of ligands with macromolecules is of crucial importance. There are many techniques for probing ligand-receptor interactions such as equilibrium dialysis, fluorescence spectroscopy, capillary electrophoresis, ultrafiltration, etc. Generally, these techniques require time-consuming separation step which might influence binding equilibria or analyte derivatization step which may change ligand activity. NMR spectroscopy is very useful method for characterization of ligand-receptor interactions since it can provide a wealth of information without destroying the sample. In this review a description of the main NMR techniques to study interactions of bioactive molecules with their biological receptors is given and their principal advantages and disadvantages are discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Predrag Novak, )

Ustanove
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Predrag Novak (autor)

Avatar Url Tomislav Jednačak (autor)

Citiraj ovu publikaciju

Novak, Predrag; Jednačak, Tomislav
NMR Spectroscopy for studying interactions of bioactive molecules // Physico-Chemical methods in Drug discovery / Mandić, Zoran (ur.).
Zagreb: IAPC, 2011. str. 1-62
Novak, P. & Jednačak, T. (2011) NMR Spectroscopy for studying interactions of bioactive molecules. U: Mandić, Z. (ur.) Physico-Chemical methods in Drug discovery. Zagreb, IAPC, str. 1-62.
@inbook{inbook, editor = {Mandi\'{c}, Z.}, year = {2011}, pages = {1-62}, keywords = {NMR techniques , drug discovery, macrolides, ribosomes, epitopes, drug design}, isbn = {978-953-56942-0-5}, title = {NMR Spectroscopy for studying interactions of bioactive molecules}, keyword = {NMR techniques , drug discovery, macrolides, ribosomes, epitopes, drug design}, publisher = {IAPC}, publisherplace = {Zagreb} }