engleski

Serotonin transporter gene polymorphisms in Crohn's disease patients

Serotonin (5-HT) is an important factor in gut function, playing key roles in intestinal peristalsis, secretion, vasodilatation and sensory signalling. The serotoninselective reuptake transporter protein (SERT) terminates the action of 5-HT. Human SERT is encoded by a single gene on chromosome 17q11 ; two important polymorphic sites in the SERT gene are: variable number tandem repeats in the gene’ s second intron (SERTin2), and an insertion/deletion in the promoter region (SERTPR). Consistent with the effects of 5-HT in the gut, SERT polymorphisms could potentially be involved in the development of IBD. The aim of this study was to evaluate the possible role of SERT polymorphisms in pathogenesis of CD.

serotonin; transport gene; Crohn's disease

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