engleski

Vasodilatory Prostaglandins in Perinatal Hypoxic Brain Damage

Prostaglandins synthesis (PGE2 and PGI2) was determined in the liquors and serum of 19 hypoxic neonates by using ELISA method. Control group consisted of 8 children of the same age whose samples were taken because initial suspicion of neonatal meningitis. The prostaglandin concentrations in liquor were correlated with initial hypoxic-ischemic encephalopathy (HIE) stage and neurological findings of patients at age of 12 months. The values of PGE2 and PGI2 in the liquor of children with PNH were significantly higher than in the children from the control group. The values of PGI2 in serum were significantly higher than in liquor of patients with PNH. Although average values of PGE2 and PGI2 in the liquor were higher in children with advanced stage of HIE, the differences between different stages were not statistically significant. We did not find any significant correlation between average concentrations of prostaglandins and neurological findings of the 12-month-old children.

hypoxic-ischemic; neonate; prostgalandin synthesis; PGE2; PGI2

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