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Pregled bibliografske jedinice broj: 554575

Botulinum toxin type A reduces migraine symptoms in rats: bilateral allodynia and dural extravasation after infraorbital nerve constriction injury


Filipovic, Boris; Matak, Ivica; Bach-Rojecky, Lidija; Lacković, Zdravko
Botulinum toxin type A reduces migraine symptoms in rats: bilateral allodynia and dural extravasation after infraorbital nerve constriction injury // Abstract for the 16th World Congress of Basic and Clinical Pharmacology (WolrdPharma 2010( ; u: Basic & Clinical Pharmacology & Toxicology 107 (2010) (S1) ; Additional Abstracts (693–697), Paper No.: 698 / Brosen, Kim (ur.).
Kopenhagen, Danska, 2010. str. 694-695 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Botulinum toxin type A reduces migraine symptoms in rats: bilateral allodynia and dural extravasation after infraorbital nerve constriction injury

Autori
Filipovic, Boris ; Matak, Ivica ; Bach-Rojecky, Lidija ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract for the 16th World Congress of Basic and Clinical Pharmacology (WolrdPharma 2010( ; u: Basic & Clinical Pharmacology & Toxicology 107 (2010) (S1) ; Additional Abstracts (693–697), Paper No.: 698 / Brosen, Kim - , 2010, 694-695

Skup
16th World Congress of Basic and Clinical Pharmacology (16 ; 2010)

Mjesto i datum
Kopenhagen, Danska, 17.-23.07.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
botulinum toxine type A; migraine; neurogenic inflammation

Sažetak
Control studies in humans indicate that botulinum toxin type A (BoNT/A) alleviates symptoms of migraine. However, this problem was never investigated in experimental animals. Infraorbital nerve constriction injury is a model used both in trigeminal neuropatic pain and in migraine. We have assessed mechanical allodynia and dural extravasation in this model after single unilateral injection of BoNT/A (3.5 U/ kg). Neuropathic behavior in rats was induced by a chronic constriction injury of the infraorbital nerve, and BoNT/A was administered into whisker pad either ipsilaterally or contralaterally to the side of nerve injury. The effects of BoNT/A on bilateral pain were assessed for a period of a month by measuring mechanical allodynia with Von Frey filaments. Animals which developed mechanical allodynia were administered with Evans blue intravenously and dural extravasation of Evans blue - plasma protein complexes was assessed. Both mechanical allodynia and dural extravasation were reduced by a single unilateral BoNT/A (3.5 U/kg) injection on the side of the toxin injection, and on the opposite side, as well. Both migraine signs: pain and dural extravasation were reduced after BoNT/A injection. For the first time we show presence of dural extravasation after infraorbital nerve constriction injury. Bilateral antinociceptive effect and even more reduction of dural extravasation suggests a central mechanism of BoNT/A actions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
DOI: 10.1111/j.1742-7843.2010.00608.x



POVEZANOST RADA


Projekti:
108-1080003-0001 - NEUROTRANSMITORI I NOVI MEHANIZMI DJELOVANJA LIJEKOVA I OTROVA (Lackovic, Zdravko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Filipovic, Boris; Matak, Ivica; Bach-Rojecky, Lidija; Lacković, Zdravko
Botulinum toxin type A reduces migraine symptoms in rats: bilateral allodynia and dural extravasation after infraorbital nerve constriction injury // Abstract for the 16th World Congress of Basic and Clinical Pharmacology (WolrdPharma 2010( ; u: Basic & Clinical Pharmacology & Toxicology 107 (2010) (S1) ; Additional Abstracts (693–697), Paper No.: 698 / Brosen, Kim (ur.).
Kopenhagen, Danska, 2010. str. 694-695 (poster, međunarodna recenzija, sažetak, znanstveni)
Filipovic, B., Matak, I., Bach-Rojecky, L. & Lacković, Z. (2010) Botulinum toxin type A reduces migraine symptoms in rats: bilateral allodynia and dural extravasation after infraorbital nerve constriction injury. U: Brosen, K. (ur.)Abstract for the 16th World Congress of Basic and Clinical Pharmacology (WolrdPharma 2010( ; u: Basic & Clinical Pharmacology & Toxicology 107 (2010) (S1) ; Additional Abstracts (693–697), Paper No.: 698.
@article{article, editor = {Brosen, K.}, year = {2010}, pages = {694-695}, keywords = {botulinum toxine type A, migraine, neurogenic inflammation}, title = {Botulinum toxin type A reduces migraine symptoms in rats: bilateral allodynia and dural extravasation after infraorbital nerve constriction injury}, keyword = {botulinum toxine type A, migraine, neurogenic inflammation}, publisherplace = {Kopenhagen, Danska} }
@article{article, editor = {Brosen, K.}, year = {2010}, pages = {694-695}, keywords = {botulinum toxine type A, migraine, neurogenic inflammation}, title = {Botulinum toxin type A reduces migraine symptoms in rats: bilateral allodynia and dural extravasation after infraorbital nerve constriction injury}, keyword = {botulinum toxine type A, migraine, neurogenic inflammation}, publisherplace = {Kopenhagen, Danska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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