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Pregled bibliografske jedinice broj: 553649

Meta analysis of vitamin D receptor polymorphisms and psoriasis risk


Štefanić, Mario; Ručević, Ivana; Barišić-Druško, Vladimira
Meta analysis of vitamin D receptor polymorphisms and psoriasis risk // International journal of dermatology, 52 (2013), 6; 705-710 doi:10.1111/j.1365-4632.2012.5813.x (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 553649 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Meta analysis of vitamin D receptor polymorphisms and psoriasis risk

Autori
Štefanić, Mario ; Ručević, Ivana ; Barišić-Druško, Vladimira

Izvornik
International journal of dermatology (0011-9059) 52 (2013), 6; 705-710

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
psoriasis; calcitriol; receptor; meta-analysis; polymorphism; genetic

Sažetak
Vitamin D receptor (VDR) gene polymorphisms have been studied as candidate variants that affect psoriasis risk. However, results have been conflicting. We reviewed studies on VDR polymorphisms and psoriasis risk published to October 1, 2011, and quantitatively summarized associations of the most widely studied variants (FokI, TaqI, ApaI, BsmI) using meta-analysis. Associations were measured using random-effect odds ratios (ORs) combined with 95% confidence intervals (CIs). Eleven eligible studies, encompassing 1106 cases and 1209 controls, were retrieved from electronic databases and included in this review. The results were heterogeneous, which may be partly explained by small sample bias, the phenomenon of winner's curse, and differences among populations. For FokI and ApaI polymorphisms, we did not find any evidence of association. A borderline allelic association was found for the BsmI B variant after exclusion of the earliest significant report (OR = 0.81, 95% CI 0.68–0.98 ; P = 0.04, inconsistency index [I 2] = 12.7%). Among Caucasian subjects, the TaqI t allele was nominally associated with psoriasis risk (OR = 0.77, 95% CI 0.64–0.97 ; P = 0.012, I 2 = 0), with homozygous carriers (tt vs. TT, OR = 0.59, 95% CI 0.39–0.90 ; P = 0.01, I 2 = 0) and recessive model (tt vs. Tt + TT, OR = 0.66, 95% CI 0.44–0.98 ; P = 0.04, I 2 = 0) as protective factors. None of these associations persisted after adjustment for multiple comparisons. No publication bias was detected in this meta-analysis. No genetic variant examined in the VDR gene showed a robust and reproducible association with risk for psoriasis. Any association that may exist is likely to be weak and potentially restricted to specific populations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
219-2190372-2068 - Polimorfizmi u genu za vitamin D receptor u psorijazi i atopijskom dermatitisu (Štefanić, Mario, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Mario Štefanić (autor)

Avatar Url Ivana Ručević (autor)

Avatar Url Vladimira Druško (autor)

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Štefanić, Mario; Ručević, Ivana; Barišić-Druško, Vladimira
Meta analysis of vitamin D receptor polymorphisms and psoriasis risk // International journal of dermatology, 52 (2013), 6; 705-710 doi:10.1111/j.1365-4632.2012.5813.x (međunarodna recenzija, članak, znanstveni)
Štefanić, M., Ručević, I. & Barišić-Druško, V. (2013) Meta analysis of vitamin D receptor polymorphisms and psoriasis risk. International journal of dermatology, 52 (6), 705-710 doi:10.1111/j.1365-4632.2012.5813.x.
@article{article, author = {\v{S}tefani\'{c}, Mario and Ru\v{c}evi\'{c}, Ivana and Bari\v{s}i\'{c}-Dru\v{s}ko, Vladimira}, year = {2013}, pages = {705-710}, DOI = {10.1111/j.1365-4632.2012.5813.x}, keywords = {psoriasis, calcitriol, receptor, meta-analysis, polymorphism, genetic}, journal = {International journal of dermatology}, doi = {10.1111/j.1365-4632.2012.5813.x}, volume = {52}, number = {6}, issn = {0011-9059}, title = {Meta analysis of vitamin D receptor polymorphisms and psoriasis risk}, keyword = {psoriasis, calcitriol, receptor, meta-analysis, polymorphism, genetic} }
@article{article, author = {\v{S}tefani\'{c}, Mario and Ru\v{c}evi\'{c}, Ivana and Bari\v{s}i\'{c}-Dru\v{s}ko, Vladimira}, year = {2013}, pages = {705-710}, DOI = {10.1111/j.1365-4632.2012.5813.x}, keywords = {psoriasis, calcitriol, receptor, meta-analysis, polymorphism, genetic}, journal = {International journal of dermatology}, doi = {10.1111/j.1365-4632.2012.5813.x}, volume = {52}, number = {6}, issn = {0011-9059}, title = {Meta analysis of vitamin D receptor polymorphisms and psoriasis risk}, keyword = {psoriasis, calcitriol, receptor, meta-analysis, polymorphism, genetic} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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