engleski

Insulin resistant brain state and drug development

Basic research of Alzheimer's disease (AD) is currently focused to the various transgenic mice AD models which have been designed by manipulation of genes involved generaly in the production of amyloid β peptide and tau protein, and are, therefore representing models of the familal AD form. However, more than 95% cases of AD are manifested as the sporadic form with unknown etiopathogenesis due to transgenic mice models are not good models for investigating the sAD patophysiology and for testing the novel therapeutic approaches in this disease. Rats treated intracerebroventricularly with a streptozotocin (STZ-icv rat model) have been recently proposed as a model of sAD, which similar to sAD patients, develop insulin resistant brain state. Pharmacological profile of novel, multifanctional compunds M30 and HLA20 which have iron-chelating and antioxidative capacity has been tested in STZ-icv rat model and their neuropreventive and neurorescue potential on cognitive deficits has been demonstrated. Supported by MZOŠ 108-1080003-0020 and DAAD.

sporadic Alzheimer disease; streptozotocin; M30; HLA-20

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