Bone morphogenetic protein (BMP)1-3 enhances bone repair (CROSBI ID 178669)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Grgurević, Lovorka ; Maček, Boris ; Merćep, Mladen ; Jelić, Mislav ; Smoljanović, Tomislav ; Erjavec, Igor ; Dumić-Čule, Ivo ; Prgomet, Stefan ; Đurđević, Dragan ; Vnuk, Dražen ; Lipar, Marija ; Stejskal, Marko ; Kufner, Vera ; Brkljačić, Jelena ; Matičić, Dražen ; Vukičević, Slobodan
engleski
Bone morphogenetic protein (BMP)1-3 enhances bone repair
Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased in patients with acute bone fracture. We hypothesized that circulating BMP1-3 might have an important role in bone repair and serve as a novel bone biomarker. When administered systemically to rats with a long bone fracture and locally to rabbits with a critical size defect of the ulna, recombinant human BMP1-3 enhanced bone healing. In contrast, neutralization of the endogenous BMP1-3 by a specific polyclonal antibody delayed the bone union. Invitro BMP1-3 increased the expression of collagen type I and osteocalcin in MC3T3-E1 osteoblast like cells, and enhanced the formation of mineralized bone nodules from bone marrow mesenchymal stem cells. We suggest that BMP1-3 is a novel systemic regulator of bone repair.
BMP1-3; Bone fracture; ECM; BMP7; Differentiation
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Podaci o izdanju
408 (1)
2011.
25-31
objavljeno
0006-291X
10.1016/j.bbrc.2011.03.109
Povezanost rada
Kliničke medicinske znanosti, Veterinarska medicina