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Pregled bibliografske jedinice broj: 552134

Bone morphogenetic protein (BMP)1-3 enhances bone repair


Grgurević, Lovorka; Maček, Boris; Merćep, Mladen; Jelić, Mislav; Smoljanović, Tomislav; Erjavec, Igor; Dumić-Čule, Ivo; Prgomet, Stefan; Đurđević, Dragan; Vnuk, Dražen et al.
Bone morphogenetic protein (BMP)1-3 enhances bone repair // Biochemical and biophysical research communications, 408 (2011), 1; 25-31 doi:10.1016/j.bbrc.2011.03.109 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 552134 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bone morphogenetic protein (BMP)1-3 enhances bone repair

Autori
Grgurević, Lovorka ; Maček, Boris ; Merćep, Mladen ; Jelić, Mislav ; Smoljanović, Tomislav ; Erjavec, Igor ; Dumić-Čule, Ivo ; Prgomet, Stefan ; Đurđević, Dragan ; Vnuk, Dražen ; Lipar, Marija ; Stejskal, Marko ; Kufner, Vera ; Brkljačić, Jelena ; Matičić, Dražen ; Vukičević, Slobodan

Izvornik
Biochemical and biophysical research communications (0006-291X) 408 (2011), 1; 25-31

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BMP1-3; Bone fracture; ECM; BMP7; Differentiation

Sažetak
Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased in patients with acute bone fracture. We hypothesized that circulating BMP1-3 might have an important role in bone repair and serve as a novel bone biomarker. When administered systemically to rats with a long bone fracture and locally to rabbits with a critical size defect of the ulna, recombinant human BMP1-3 enhanced bone healing. In contrast, neutralization of the endogenous BMP1-3 by a specific polyclonal antibody delayed the bone union. Invitro BMP1-3 increased the expression of collagen type I and osteocalcin in MC3T3-E1 osteoblast like cells, and enhanced the formation of mineralized bone nodules from bone marrow mesenchymal stem cells. We suggest that BMP1-3 is a novel systemic regulator of bone repair.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Veterinarska medicina



POVEZANOST RADA


Projekti:
108-1080327-0320 - Uloga TSH u modelu osteoporoze i u bolesnica sa smanjenom koštanom masom (Vukičević, Slobodan, MZOS ) ( POIROT)

Ustanove:
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinika za traumatologiju

Poveznice na cjeloviti tekst rada:

doi ac.els-cdn.com www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Grgurević, Lovorka; Maček, Boris; Merćep, Mladen; Jelić, Mislav; Smoljanović, Tomislav; Erjavec, Igor; Dumić-Čule, Ivo; Prgomet, Stefan; Đurđević, Dragan; Vnuk, Dražen et al.
Bone morphogenetic protein (BMP)1-3 enhances bone repair // Biochemical and biophysical research communications, 408 (2011), 1; 25-31 doi:10.1016/j.bbrc.2011.03.109 (međunarodna recenzija, članak, znanstveni)
Grgurević, L., Maček, B., Merćep, M., Jelić, M., Smoljanović, T., Erjavec, I., Dumić-Čule, I., Prgomet, S., Đurđević, D. & Vnuk, D. (2011) Bone morphogenetic protein (BMP)1-3 enhances bone repair. Biochemical and biophysical research communications, 408 (1), 25-31 doi:10.1016/j.bbrc.2011.03.109.
@article{article, author = {Grgurevi\'{c}, Lovorka and Ma\v{c}ek, Boris and Mer\'{c}ep, Mladen and Jeli\'{c}, Mislav and Smoljanovi\'{c}, Tomislav and Erjavec, Igor and Dumi\'{c}-\v{C}ule, Ivo and Prgomet, Stefan and \DJur\djevi\'{c}, Dragan and Vnuk, Dra\v{z}en and Lipar, Marija and Stejskal, Marko and Kufner, Vera and Brklja\v{c}i\'{c}, Jelena and Mati\v{c}i\'{c}, Dra\v{z}en and Vuki\v{c}evi\'{c}, Slobodan}, year = {2011}, pages = {25-31}, DOI = {10.1016/j.bbrc.2011.03.109}, keywords = {BMP1-3, Bone fracture, ECM, BMP7, Differentiation}, journal = {Biochemical and biophysical research communications}, doi = {10.1016/j.bbrc.2011.03.109}, volume = {408}, number = {1}, issn = {0006-291X}, title = {Bone morphogenetic protein (BMP)1-3 enhances bone repair}, keyword = {BMP1-3, Bone fracture, ECM, BMP7, Differentiation} }
@article{article, author = {Grgurevi\'{c}, Lovorka and Ma\v{c}ek, Boris and Mer\'{c}ep, Mladen and Jeli\'{c}, Mislav and Smoljanovi\'{c}, Tomislav and Erjavec, Igor and Dumi\'{c}-\v{C}ule, Ivo and Prgomet, Stefan and \DJur\djevi\'{c}, Dragan and Vnuk, Dra\v{z}en and Lipar, Marija and Stejskal, Marko and Kufner, Vera and Brklja\v{c}i\'{c}, Jelena and Mati\v{c}i\'{c}, Dra\v{z}en and Vuki\v{c}evi\'{c}, Slobodan}, year = {2011}, pages = {25-31}, DOI = {10.1016/j.bbrc.2011.03.109}, keywords = {BMP1-3, Bone fracture, ECM, BMP7, Differentiation}, journal = {Biochemical and biophysical research communications}, doi = {10.1016/j.bbrc.2011.03.109}, volume = {408}, number = {1}, issn = {0006-291X}, title = {Bone morphogenetic protein (BMP)1-3 enhances bone repair}, keyword = {BMP1-3, Bone fracture, ECM, BMP7, Differentiation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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