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CSF total tau and tau protein phosphorylated at threonine 181 in the differential diagnosis of Alzheimer's disease and vascular cognitive impairment


Boban, Marina; Šarac, Helena; Mladinov, Mihovil; Süßmair, Christine; Ackl, Nibal; Bader, Benedikt; Danek, Adrian; Mimica, Ninoslav; Hof, Patrick R; Šimić, Goran
CSF total tau and tau protein phosphorylated at threonine 181 in the differential diagnosis of Alzheimer's disease and vascular cognitive impairment // European Journal of Neurology 18 (Suppl. 2) - Abstracts of the 15th congress of the European Federation of Neurological Societies
Budimpešta, Mađarska, 2011. str. 414-414 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
CSF total tau and tau protein phosphorylated at threonine 181 in the differential diagnosis of Alzheimer's disease and vascular cognitive impairment

Autori
Boban, Marina ; Šarac, Helena ; Mladinov, Mihovil ; Süßmair, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian ; Mimica, Ninoslav ; Hof, Patrick R ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Neurology 18 (Suppl. 2) - Abstracts of the 15th congress of the European Federation of Neurological Societies / - , 2011, 414-414

Skup
15th congress of the European Federation of Neurological Societies

Mjesto i datum
Budimpešta, Mađarska, 09-13.09.2011.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Cerebrospinal fluid; dementia; Alzheimer's disease; vascular cognitive impairment

Sažetak
Alzheimer's disease (AD) and vascular cognitive impairment (VCI) are the two most common causes of dementia in older age groups. Due to inadequacy of current clinical diagnostic criteria in differential diagnosis of dementia, the identification of new biomarkers that would help establishing the diagnosis and primary cause of the dementia is therefore of great relevance. The aim of this study was to investigate the diagnostic accuracy of two potential CSF biomarkers, total tau protein (t-tau) and tau protein phosphorylated at threonine 181 (p-tau181) in the differential diagnosis of patients with AD and VCI. The concentrations of CSF biomarkers were measured in 29 AD patients, 12 VCI patients and 25 control subjects. The CSF concentrations of both markers were significantly higher in AD group compared to VCI (p>0.001) group and control subjects (p<0.001) ; however none fulfilled the criteria for the "ideal" marker (sensitivity and specificity higher than 85%). Finally, using logistic regression analysis with t-tau and p-tau181 as independent variables led to improvement in diagnostic accuracy with correct classification in more than 85% of cases.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1080003-0019 - Klinička farmakologija poremećaja pokreta (Maja Relja, )
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )

Ustanove
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE