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The effect of pentadecapeptide BPC 157 and high dose diclofenac on induced short bowel syndrome


Lojo, Nermin; Rašić, Žarko; Barić, Marko; Sever, Marko; Romić, Željko; Seiwerth, Sven; Sikirić, Predrag
The effect of pentadecapeptide BPC 157 and high dose diclofenac on induced short bowel syndrome // Abstracts of the ….. ; u: Gastroenterology 140 (2011) (5/S1) ;, 2011. str. S-505 (poster, nije recenziran, sažetak, znanstveni)


Naslov
The effect of pentadecapeptide BPC 157 and high dose diclofenac on induced short bowel syndrome

Autori
Lojo, Nermin ; Rašić, Žarko ; Barić, Marko ; Sever, Marko ; Romić, Željko ; Seiwerth, Sven ; Sikirić, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the ….. ; u: Gastroenterology 140 (2011) (5/S1) ; / - , 2011, S-505

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Short bowel sindrome; BPC 157; diclofenac

Sažetak
Stable gastric pentadecapeptide BPC 157 (an anti-ulcer peptide effective in IBD trials, LD1 not achieved) counteracted short bowel syndrome (Sever et al., Dig Dis Sci, 2009) and protected rats against diclofenac gastrointestinal injuries (Ilic et al., J Physiol Pharmacol, 2009). Aim: In this study we tested the effect of pentadecapeptide 157 on induced short bowel syndrome rats aggravated with high dose of diclofenac. Material and methods We used 80%-small intestine resection and then short bowel syndrome rats received diclofenac application (12.5 mg/kg i.p.). Medication (BPC 157 10 μg/kg or an equivolume of saline (5 ml/kg ip) was given immediately after diclofenac. Animals were sacrificed 24 h after the surgery. Assessment included bleeding period (sec), gastrointestinal lesions (sum of longest diameters of lesions stomach, small and large intestine), serum AST, ALT, bilirubine levels. Microscopic analysis was also performed. Results All BPC 157 treated animals had shorter bleeding period compared to control group animals (210 +/- 37s vrs. 480 +/- 43 s). Bilirubine levels were significantly increased in control group animals compared to BPC 157 treated animals ( 192.3 +/- 46.7 μmol/ L vrs 6.8+/- 3.1 μmol/L). AST, ALT, LDH were increased in both tested groups (AST: 308+/-14 u/L (BPC157) vrs 383+/-27 u/L (con.) ; ALT: 52+/-4 u/L (BPC157) vrs 63+/-6 u/L (con.)) Number of gastrointestinal lesions (gastric, duodenal, small and large intestinal ulcerations) was significantly larger in control animal group compared to BPC 157 treated animals (gastric: 5.6 +/- 2.7 lesions (con) vrs . 0.5+/-0.2 lesions (BPC) ; duodenal (1.3 +/-0.2 lesions(con) vrs 0 lesions (BPC) ; jejunum, ileum and rectum score (1- ulcerations, 2- erosions and erithema, 3- normal mucosal surface) ; Jejunum: 1.6+/- 0, 7(con) vrs 2.8+/-0.2 (BPC) ; Ileum: 1 +/- 0, 4 (con) vrs 2.8+/-2 (BPC) ; Rectum 1+/-0.3 (con) vrs 2.6 +/- 0, 4 (BPC)). Conclusion According to our results we could conclude that BPC 157 improves small bowel and liver lesions healing in malnutrition conditions even during high dose diclofenac exposure.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Predrag Sikirić, )
108-1083570-3643 - Kvantitativna analiza i prijenos slike u patologiji (Sven Seiwerth, )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Predrag Sikirić (autor)

Avatar Url Sven Seiwerth (autor)

Avatar Url Žarko Rašić (autor)

Avatar Url Željko Romić (autor)

Avatar Url Marko Sever (autor)

Citiraj ovu publikaciju

Lojo, Nermin; Rašić, Žarko; Barić, Marko; Sever, Marko; Romić, Željko; Seiwerth, Sven; Sikirić, Predrag
The effect of pentadecapeptide BPC 157 and high dose diclofenac on induced short bowel syndrome // Abstracts of the ….. ; u: Gastroenterology 140 (2011) (5/S1) ;, 2011. str. S-505 (poster, nije recenziran, sažetak, znanstveni)
Lojo, N., Rašić, Ž., Barić, M., Sever, M., Romić, Ž., Seiwerth, S. & Sikirić, P. (2011) The effect of pentadecapeptide BPC 157 and high dose diclofenac on induced short bowel syndrome. U: Abstracts of the ….. ; u: Gastroenterology 140 (2011) (5/S1) ;.
@article{article, year = {2011}, pages = {S-505-S-505}, keywords = {short bowel sindrome, BPC 157, diclofenac}, title = {The effect of pentadecapeptide BPC 157 and high dose diclofenac on induced short bowel syndrome}, keyword = {short bowel sindrome, BPC 157, diclofenac} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE