Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats. (CROSBI ID 89794)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Sikirić, Predrag ; Seiwerth, Sven ; Grabarević, Željko ; Ručman, Rudolf ; Petek, Marijan ; Jagić, Vjekoslav ; Turković, Branko ; Rotkvić, Ivo ; Miše, Stjepan ; Zoričić, Ivan et al. Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats. // Digestive diseases and sciences, 41 (1996), 7; 1518-1526

Podaci o odgovornosti

Sikirić, Predrag ; Seiwerth, Sven ; Grabarević, Željko ; Ručman, Rudolf ; Petek, Marijan ; Jagić, Vjekoslav ; Turković, Branko ; Rotkvić, Ivo ; Miše, Stjepan ; Zoričić, Ivan ; Jurina, Ljubica ; Konjevoda, Paško ; Hanževački, Miro ; Ljubanović, Danica ; Šeparović, Jadranka ; Gjurašin, Miro ; Bratulić, Mirna ; Artuković, Branka ; Jelovac, Nikola ; Buljat, Gojko

engleski

Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats.

The superior effectiveness of a new pentadecapeptide, BPC 157, on gastrointestinal and liver lesions, in conjunction with an antiinflammatory and analgetic activity was recently noted. In the present study, BPC 157 was tested as either a protective or healing agent in bile duct ligation-induced acute pancreatitis in rats. In addition, the positive influence of BPC 157 on concomitantly developed gastric and duodenal lesions was simultaneously investigated. BPC 157 (10 microg, 10 ng/kg body wt, intraperitoneally or intragastrically) was given prophylactically 1 hr before ligation, whereas the therapy was given once daily beginning with the 24 hr following ligation (last application 24 hr before killing). The effect was investigated at daily intervals until the end of the fifth day after ligation. In the pretreatment regimen, a strong pancreas protection was obtained. When applied in the condition of already established severe acute pancreatitis, an obvious salutory effect was consistently noted. Assessing the appearance of the necrosis, edema, neutrophils, and mononuclears, consistently less necrosis, edema, and neutrophils, but more mononuclears, were found in BPC-treated rats. Likewise, in studies of the serum amylase values, relative to control data, a markedly lower rise (BPC pretreatment regimen) as well as a worsening of the already raised values (BPC therapy regimen) was noted. Along with its beneficial effect on pancreatitis, a positive influence of BPC 157 on the gastric and duodenal lesion course in bile duct- ligated rats was noted in both the pre- and posttreatment regimen. Taken together, in further studies of acute pancreatitis therapy, BPC could be an interesting and useful agent with an additional positive impact on concomitant gastroduodenal pathology.

pentadekapeptide BPC 157 ; acute pancreatitis ; gastroduodenal lesions

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

41 (7)

1996.

1518-1526

objavljeno

0163-2116

1573-2568

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost