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Pregled bibliografske jedinice broj: 550561

Stam2 expression pattern during embryo development


Ćurlin, Marija; Kapuralin, Katarina; Muro, Andres F; Baralle, Francisco E; Kamal, Chowdury; Gajović, Srećko
Stam2 expression pattern during embryo development // GENE EXPRESSION PATTERNS, 12 (2012), 1-2; 68-76 (međunarodna recenzija, članak, znanstveni)


Naslov
Stam2 expression pattern during embryo development

Autori
Ćurlin, Marija ; Kapuralin, Katarina ; Muro, Andres F ; Baralle, Francisco E ; Kamal, Chowdury ; Gajović, Srećko

Izvornik
GENE EXPRESSION PATTERNS (1567-133X) 12 (2012), 1-2; 68-76

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
STAM2; gene trap; mouse; embryo; expression; X-gal staining; development

Sažetak
STAM2 is a tyrosine-phosphorylated protein suggested to be involved in cargo selection 3 during endocytic pathway, regulation of exocytosis and intracellular signaling. Gene trap 4 method was used to create via insertional mutagenesis a mutant mouse line with integration of 5 promoterless βgeo (lacZ-neomycin phosphotransferase fusion) gene in the second intron of 6 Stam2 gene, enabling analysis of its in vivo expression and function. The inserted β- 7 galactosidase (lacZ) reporter gene was used to reveal Stam2 expression during development. 8 Stam2 in situ RNA hybridization and immunostaining confirmed the observed β-galactosidase 9 activity reflecting high Stam2 expression. 10 The homozygous mutant mice showed no overt phenotypic alterations. Stam2 expression was 11 detected after E9.5 in the gut, notochord, neural tube and heart. In the nervous system it was 12 located in the floor, roof and basal plates of the developing neural tube, and in the developing 13 cortex, hippocampus and olfactory bulbs. Toward the end of gestation, Stam2 expression 14 appeared in the testis and ovary, lungs, nasal cavity epithelium, kidneys, urogenital sinus, 15 intestine, pancreas, pituitary and adrenal glands, muscles, brown adipose tissue, skin and 16 epithelium of the tongue and oral cavity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081870-1902 - Uloga gena u diferencijaciji i plastičnosti središnjeg živčanog sustava miša (Srećko Gajović, )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Srećko Gajović (autor)

Avatar Url Marija Ćurlin (autor)

Avatar Url Katarina Kapuralin (autor)

Citiraj ovu publikaciju

Ćurlin, Marija; Kapuralin, Katarina; Muro, Andres F; Baralle, Francisco E; Kamal, Chowdury; Gajović, Srećko
Stam2 expression pattern during embryo development // GENE EXPRESSION PATTERNS, 12 (2012), 1-2; 68-76 (međunarodna recenzija, članak, znanstveni)
Ćurlin, M., Kapuralin, K., Muro, A., Baralle, F., Kamal, C. & Gajović, S. (2012) Stam2 expression pattern during embryo development. GENE EXPRESSION PATTERNS, 12 (1-2), 68-76.
@article{article, year = {2012}, pages = {68-76}, keywords = {STAM2, gene trap, mouse, embryo, expression, X-gal staining, development}, journal = {GENE EXPRESSION PATTERNS}, volume = {12}, number = {1-2}, issn = {1567-133X}, title = {Stam2 expression pattern during embryo development}, keyword = {STAM2, gene trap, mouse, embryo, expression, X-gal staining, development} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE