engleski

Level of vascular endothelial growth factor in recurent aphthous ulceration

Saliva contains biologically active proteins such as several different growth factors, cytokines and prostaglandins. This study investigated slivary level of vascular endothelial growth factor in 30 patients with minor and major reccurent aphthous ulceration (RAU)and 27 age matched healthy controls. VEGF was determined by ELISA in resting whole saliva of all participants. The devolepment of of recurrent aphtous lesions was divided into stages: (1) early prodromal stage (mucosal redness or erosion), (2) active disease (frank ulceration) and (3) remission stage. Significantly lower level of salivary VEGF (p<0, 001) was found in patients with major RAU during active disease when compared to the controls. Statistical analysiswas done by Student-t test. The mean ąSD were 327, 02ą 113, 05 pg/ml in acute stage of major RAUand 1488, 88ą 605, 38 pg/ml in healthy controls. Salivary VEGF showed stage dependent alterations as well as variatoins regarding the type of ulcers. The VEGF concentration decreased significantly during the active stage of a disease and increased during the remission period in patient with major RAU. No differences in salivary VEGF in patients with acute minor RAU as well as during the remission period when compared to control was found. In conclusion, diminuation of salivary VEGF in acute stage of major RAU suggesting active involvement of this compound in the pathogenesis of the disease. It also sugested that VEGF may also have cytoprotective role in homeostasis of oral cavity.

saliva; vascular endothelial growth factor; aphthous ulceration

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