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Pregled bibliografske jedinice broj: 550074

Reaction kinetics and mechanical models of liposome adhesion at charged interface


Ivošević DeNardis, Nadica; Ružić, Ivica; Pečar- Ilić, Jadranka; El Shawish, Samir; Ziherl, Primož
Reaction kinetics and mechanical models of liposome adhesion at charged interface // Bioelectrochemistry (Amsterdam), 88 (2012), 48-56 doi:10.1016/j.bioelechem.2012.05.003 (međunarodna recenzija, članak, znanstveni)


Naslov
Reaction kinetics and mechanical models of liposome adhesion at charged interface

Autori
Ivošević DeNardis, Nadica ; Ružić, Ivica ; Pečar- Ilić, Jadranka ; El Shawish, Samir ; Ziherl, Primož

Izvornik
Bioelectrochemistry (Amsterdam) (1567-5394) 88 (2012); 48-56

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adhesion force; chronoamperometry; current transient; liposome adhesion; mechanical model; reaction kinetics model

Sažetak
Dynamics of adhesion of single liposome at the charged mercury interface is analysed through its amperometric signal using a reaction kinetics model and a mechanical model. We present analytical solutions of the reaction kinetics model for decoupling and identifying temporal evolution of three distinct states: i) the initial state corresponding to an intact liposome, ii) the intermediate state where the liposome is partly deformed, and iii) the final state of a lipid layer formation. The results obtained with this model indicate that all three states simultaneously evolve from the onset of the adhesion process. The new mechanical model provides a physical interpretation of the three states and emphasises the role of the forces involved in liposome adhesion process. The main conclusion is that the water content of the liposome is released through the pores formed in the membrane rather than through the channels parallel to the electrode. Both models reproduce the measurements well and offer a complementary insight into the dynamics of single adhesion event, which can find application in studies of cell adhesion and in drug delivery.

Izvorni jezik
Engleski

Znanstvena područja
Geologija, Kemija, Elektrotehnika



POVEZANOST RADA


Projekt / tema
098-0982934-2723 - Informacijski sustavi o kakvoći okoliša i procjeni okolišnog rizika (Jadranka Pečar Ilić, )
098-0982934-2744 - Površinske sile na atomskoj skali u istraživanju mora i nanotehnologiji (Vesna Svetličić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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