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Interactions of acyclic and cyclic polyamines with DNA and RNA


Piantanida, Ivo; García-España, E.; Sornosa-Ten, A.; Albelda, M.T.; Frías, J.C; Llinares, J.M.; Budimir, Ana; González Garcia, J.
Interactions of acyclic and cyclic polyamines with DNA and RNA // The 3rd EuCheMS Chemistry
Nurnberg, Njemačka, 2010. (poster, nije recenziran, sažetak, znanstveni)


Naslov
Interactions of acyclic and cyclic polyamines with DNA and RNA

Autori
Piantanida, Ivo ; García-España, E. ; Sornosa-Ten, A. ; Albelda, M.T. ; Frías, J.C ; Llinares, J.M. ; Budimir, Ana ; González Garcia, J.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
The 3rd EuCheMS Chemistry

Mjesto i datum
Nurnberg, Njemačka, 28. 8. - 3. 9. 2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Cyclic polyamines; DNA; RNA; selectivity

Sažetak
A series of novel cyclic polyamines differing from acyclic derivatives in a number of positive charges, as well as in type and location of heteroaromatic moieties were studied for binding ability to double stranded DNA and RNA. All applied methods (UV/vis, fluorimetric, CD titrations, melting experiments) consistently support binding of cyclic polyamines within the DNA minor groove, while for ds-RNA binding mode is not clearly defined. Both, acyclic (A) and cyclic (B) polyamines reveal pronounced ds-RNA over ds-DNA selectivity, whereby selectivity of cyclic derivatives depends on a core moiety (pyridine vs. phenanthroline).

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb