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izvor podataka: crosbi

mRNA expression of bone morphogenetic proteins and their receptors in human renal cell carcinoma (CROSBI ID 178264)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Markić, Dean ; Ćelić, Tanja ; Gršković, Antun ; Španjol, Josip ; Fučkar, Željko ; Grahovac, Blaženka ; Đorđević, Gordana ; Bobinac, Dragica mRNA expression of bone morphogenetic proteins and their receptors in human renal cell carcinoma // Urologia internationalis, 87 (2011), 3; 353-358. doi: 10.1159/000330797

Podaci o odgovornosti

Markić, Dean ; Ćelić, Tanja ; Gršković, Antun ; Španjol, Josip ; Fučkar, Željko ; Grahovac, Blaženka ; Đorđević, Gordana ; Bobinac, Dragica

engleski

mRNA expression of bone morphogenetic proteins and their receptors in human renal cell carcinoma

Bone morphogenetic proteins (BMPs) have been studied in several cancers, but only limited information is available about renal cell carcinomas (RCCs). We determined the expression of mRNA of several BMP ligands and BMP receptors (BMPRs) in healthy kidney tissue and RCCs, and data were compared to clinicopathological parameters. Sixty-four samples of RCCs and healthy renal tissues were prospectively examined. The expression of BMP2, BMP4, BMP6, BMP7, BMPRIA, BMPRIB and BMPRII mRNA was determined using semiquantitative reverse transcriptase-polymerase chain reaction. The expression levels of different BMP ligands and BMPRs were considerably higher in RCCs than in normal kidney tissue. BMP ligands showed elevated expression in clear-cell RCCs, whereas all three BMPRs showed higher expression levels in non- clear-cell RCCs. In clear-cell RCCs, the expression levels of BMP2 progressively increased and expression levels of BMP6, BMP7 and BMPRIB were lost with higher tumor stage. All BMPs and their receptors have stronger expression levels in RCC. The expression level of BMP2 is strongly elevated in kidney cancer.

bone morphogenetic protein; renal cell carcinoma; kidney

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Podaci o izdanju

87 (3)

2011.

353-358

objavljeno

0042-1138

10.1159/000330797

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

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