engleski

Relationship between obesity and prostate cancer

Introduction It is well known that, beside age, race and familiar factor, dietary factors play big role in epidemiology of prostate cancer (CaP). The Western lifestyle, particularly the higher intake of fat, meat, and dairy products, is also associated with risk for CaP. Obesity is also linked to CaP, mainly with mortality rather than incidence. We wanted to see and show if there is difference in body mass index (BMI) in patients with biopsy diagnosed CaP and patients in control group. Patients and methods We have included 235 patients in our research was (age 42-84 yrs.). In all patients transrectal biopsy of prostate was done. In 117 patients out of 235 is diagnosed CaP, in rest of 118 patients patohistological finding did not show CaP (control group). BMI and PSA level were determinated to all patients. Student t-test was used to assign difference between BMI in our 2 groups. Results Mean BMI in group of patients with CaP was 27.625 kg/m2 (SD 5.680), mean BMI in control group was 27.692 kg/m2 (SD 3.987). There was no statistical significant difference in BMI in out two groups. When we grouped our patients according to their BMI (underweight < 18, 5 kg/m2 ; normal 18, 5-25 kg/m2 ; overweight 25-30 kg/m2 and obese >30 kg/m2), we noticed decrease of PSA level with increase of BMI. In our research there was no underweight patients, 64 of them were with normal BMI and mean PSA 69.48 ng/ml ; 120 of them were overweight with mean PSA 55.15 ng/ml and 51 of them were obese patients with mean PSA 33.16 ng/ml. Discussion General adiposity, as measured by BMI, is not in relationship with CaP incidention in our research, but obese is connected with lower PSA level with possible hemodilution in background. Question is – should we decrease the threshold of PSA in obese patients for prostate biopsy?

obesity ; prostate cancer

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