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CD4+CD25+FOXP3+ TREG IN STABLE ADULT CADAVERIC KIDNEY TRANSPLANT RECIPIENTS


Zibar, Lada; Barbić, Jerko; Dobrošević, Blaženka
CD4+CD25+FOXP3+ TREG IN STABLE ADULT CADAVERIC KIDNEY TRANSPLANT RECIPIENTS // Acta Medica Croatica
Split, Hrvatska: Akademija medicinskih znanosti Hrvatske, 2011. str. 150-150 (predavanje, nije recenziran, sažetak, znanstveni)


Naslov
CD4+CD25+FOXP3+ TREG IN STABLE ADULT CADAVERIC KIDNEY TRANSPLANT RECIPIENTS

Autori
Zibar, Lada ; Barbić, Jerko ; Dobrošević, Blaženka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta Medica Croatica / - : Akademija medicinskih znanosti Hrvatske, 2011, 150-150

Skup
6. Hrvatski kongres nefrologije, dijalize i transplantacije

Mjesto i datum
Split, Hrvatska, 07.-10.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
CD4+CD25+FOXP3+ lymphocytes; kidney transplant recipients; immune tolerance potentiale

Sažetak
Introduction. Recent studies suggest that CD4+CD25+FOXP3+ lymphocytes may bear immune tolerance toward kidney allograft. Aim. Aim was to determine concentration of CD4+CD25+FOXP3+ regulatory T lymphocytes (TREG) among peripheral mononuclear lymphocytes (PMNL) in stable cadaveric kidney transplant recipients. Patients and methods. Study included functionally stable 53 patients (23 males ; 50±12 years in age), with the first cadaveric kidney transplant received before at least a year (median 4 years, min. 1, max. 22). Patients suffered of miscellaneous basic kidney diseases and were treated with standard immunosuppression. Their GFR (expressed as creatinine clearance) was 68±27 ml/min. They underwent regular check-ups in a single centre. PMNL were isolated on Ficoll-paque density gradient and fenotyped by flow cytometry using monoclonal antibodies against CD4, CD25 and intracellular transcription factor FOXP3. Results. Peripheral leukocyte count was 7.8±2.4x109/l, 28±9% of them were lymphocytes. Among isolated PMNL there was 38.92±8.88% CD4+, 2.36±0.72% CD4+CD25+ and 2.06±0.65 CD4+CD25+FOXP3+. CD4+CD25+FOXP3+ presented 88±12% of CD4+CD25+ lymphocytes. There was significant positive correlation between concentrations of CD4+, CD4+CD25+ and CD4+CD25+FOXP3+, and linear regression between CD4+CD25+ and CD4+CD25+FOXP3+ (R-square=0.78). No gender difference was found. Age significantly positively correlated with concentrations of CD4+CD25+ and CD4+CD25+FOXP3+ cells (p=0.009), respectively. Time after transplantation, donor’s age, dialysis duration, HLA mismatches number or medication did not affect TREG concentration. Those received kidney from donors having blood group 0 had significantly higher concentrations of CD4+CD25+FOXP3+ lymphocytes, but also CD4+ and CD4+CD25+ cells. Conclusion. Stable kidney recipients had normally distributed concentration of CD4+CD25+FOXP3+ TREG, around 2% of PMNL. Most of the CD4+CD25+ lymphocytes were also FOXP3+. It seems that higher immune tolerance potential could favour older age of recipients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
219-0000000-3362 - Genski polimorfizam i funkcija bubrežnog presatka (Jerko Barbić, )

Ustanove
Medicinski fakultet, Osijek

Profili:

Avatar Url Jerko Barbić (autor)

Avatar Url Lada Zibar (autor)

Citiraj ovu publikaciju

Zibar, Lada; Barbić, Jerko; Dobrošević, Blaženka
CD4+CD25+FOXP3+ TREG IN STABLE ADULT CADAVERIC KIDNEY TRANSPLANT RECIPIENTS // Acta Medica Croatica
Split, Hrvatska: Akademija medicinskih znanosti Hrvatske, 2011. str. 150-150 (predavanje, nije recenziran, sažetak, znanstveni)
Zibar, L., Barbić, J. & Dobrošević, B. (2011) CD4+CD25+FOXP3+ TREG IN STABLE ADULT CADAVERIC KIDNEY TRANSPLANT RECIPIENTS. U: Acta Medica Croatica.
@article{article, year = {2011}, pages = {150-150}, keywords = {CD4+CD25+FOXP3+ lymphocytes, kidney transplant recipients, immune tolerance potentiale}, title = {CD4+CD25+FOXP3+ TREG IN STABLE ADULT CADAVERIC KIDNEY TRANSPLANT RECIPIENTS}, keyword = {CD4+CD25+FOXP3+ lymphocytes, kidney transplant recipients, immune tolerance potentiale}, publisher = {Akademija medicinskih znanosti Hrvatske}, publisherplace = {Split, Hrvatska} }