Lipid bound sialic acid, PGE and histamine in head and neck cancer (CROSBI ID 178032)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Klapan, Ivica ; Katić, Vladimir ; Čulo, Filip ; Sabolović, Domagoj ; Ćuk, Višeslav
engleski
Lipid bound sialic acid, PGE and histamine in head and neck cancer
Blood concentration of lipid-bound sialic acid (LBSA), prostaglandin E (PGE) and histamine were determined in 37 patients with carcinoma of hypopharynx and larynx (supraglottic and glottic), in 12 non-cancer patients and in 10 healthy subjects. The concentration of LBSA was significantly increased in 94.4% cancer patients preoperatively and fell to somewhat lower levels within 1 month after tumour resection. In patients with complete tumour resection and no tumour recurrences within 2 years, it steadily decreased thereafter, reaching normal levels within 6-24 months after surgery, whereas in patients with tumour recurrences or incomplete tumour resection it rose again within 6 months after tumour resection. Similarly, the concentration of PGE was significantly increased in about two thirds of cancer patients (67.6%) preoperatively, dropped significantly within 1 month after tumour resection and rose again in patients with tumour recurrences. Preoperative histamine concentration was decreased in 24.3% of cancer patients and postoperatively it rose both in patients with or without tumour recurrences.
head and neck cancer; lipid-bound sialic acid; PGE2; histamine
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Podaci o izdanju
Povezanost rada
Kliničke medicinske znanosti