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Pregled bibliografske jedinice broj: 548280

Oxidative stress parameters in different brain structures following lateral fluid percussion injury in the rat


Pilipović, Kristina; Župan, Željko; Dangubić, Boban; Mršić-Pelčić, Jasenka; Župan, Gordana
Oxidative stress parameters in different brain structures following lateral fluid percussion injury in the rat // Neurochemical research, 36 (2011), 5; 913-921 doi:10.1007/s11064-011-0424-3 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 548280 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Oxidative stress parameters in different brain structures following lateral fluid percussion injury in the rat

Autori
Pilipović, Kristina ; Župan, Željko ; Dangubić, Boban ; Mršić-Pelčić, Jasenka ; Župan, Gordana

Izvornik
Neurochemical research (0364-3190) 36 (2011), 5; 913-921

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Brain injury; brain trauma; oxidative stress; rat

Sažetak
Free radicals mediated damage of phospholipids, proteins and nucleic acids results in subsequent neuronal degeneration and cell loss. Aim of this study was to evaluate the existence of lipid and protein oxidative damage and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in various rat brain structures 24 h after lateral fluid percussion brain injury (LFPI). Parietal cortex, hippocampus, thalamus, entorhinal cortex, and cerebellum from the ipsilateral hemisphere were processed for analyses of the thiobarbituric acid reactive substances (TBARS) and oxidized protein levels as well as for the SOD and GSH-Px activities. Immunohistochemical detection of oxidized proteins was also performed. Results of our study showed that LFPI caused significant oxidative stress in the parietal cortex and hippocampus while other brain regions tested in this study were not oxidatively altered by LFPI. GSH-Px activities were significantly increased in the parietal cortex and hippocampus, while the SOD activities remained unchanged following LFPI in all regions investigated.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620529-0518 - Molekularni mehanizmi ishemijskog oštećenja mozga i neuroprotekcija (Mršić-Pelčić, Jasenka, MZOS ) ( POIROT)
062-0620529-0519 - Epilepsija i traumatska ozljeda mozga: mehanizmi oštećenja i farmakoterapija (Župan, Gordana, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Pilipović, Kristina; Župan, Željko; Dangubić, Boban; Mršić-Pelčić, Jasenka; Župan, Gordana
Oxidative stress parameters in different brain structures following lateral fluid percussion injury in the rat // Neurochemical research, 36 (2011), 5; 913-921 doi:10.1007/s11064-011-0424-3 (međunarodna recenzija, članak, znanstveni)
Pilipović, K., Župan, Ž., Dangubić, B., Mršić-Pelčić, J. & Župan, G. (2011) Oxidative stress parameters in different brain structures following lateral fluid percussion injury in the rat. Neurochemical research, 36 (5), 913-921 doi:10.1007/s11064-011-0424-3.
@article{article, year = {2011}, pages = {913-921}, DOI = {10.1007/s11064-011-0424-3}, keywords = {Brain injury, brain trauma, oxidative stress, rat}, journal = {Neurochemical research}, doi = {10.1007/s11064-011-0424-3}, volume = {36}, number = {5}, issn = {0364-3190}, title = {Oxidative stress parameters in different brain structures following lateral fluid percussion injury in the rat}, keyword = {Brain injury, brain trauma, oxidative stress, rat} }
@article{article, year = {2011}, pages = {913-921}, DOI = {10.1007/s11064-011-0424-3}, keywords = {Brain injury, brain trauma, oxidative stress, rat}, journal = {Neurochemical research}, doi = {10.1007/s11064-011-0424-3}, volume = {36}, number = {5}, issn = {0364-3190}, title = {Oxidative stress parameters in different brain structures following lateral fluid percussion injury in the rat}, keyword = {Brain injury, brain trauma, oxidative stress, rat} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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