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Pregled bibliografske jedinice broj: 548136

Induction and maintenance of allergen-specific FOXP31 Treg cells in human tonsils as potential first-line organs of oral tolerance


Palomares, Oscar; Ruckert, Beate; Jartti, T; Kucuksezer, Umut C; Puhakka, T; Gomez, E; Fahrner HB; Speiser, A; Jung, A; Kwok, WW et al.
Induction and maintenance of allergen-specific FOXP31 Treg cells in human tonsils as potential first-line organs of oral tolerance // Journal of allergy and clinical immunology (2011) (ostalo, prihvaćen)


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Naslov
Induction and maintenance of allergen-specific FOXP31 Treg cells in human tonsils as potential first-line organs of oral tolerance

Autori
Palomares, Oscar ; Ruckert, Beate ; Jartti, T ; Kucuksezer, Umut C ; Puhakka, T ; Gomez, E ; Fahrner HB ; Speiser, A ; Jung, A ; Kwok, WW ; Kalogjera, L ; Akdis, Mubeccel ; Akdis, Cezmi A

Vrsta, podvrsta
Radovi u časopisima, ostalo

Izvornik
Journal of allergy and clinical immunology (2011)

Status rada
Prihvaćen

Ključne riječi
Immune tolerance; tonsils; allergen-specific Treg cells;

Sažetak
Background: Tonsils are strategically located in the gateway of both alimentary and respiratory tracts representing the first contact point of food and aeroallergens with the immune system. Tonsillectomy removes only the palatine tonsils and sometimes adenoids. Lingual tonsil is anatomically big and remains lifelong intact. Objective: The aim of this study was to demonstrate cellular and molecular mechanisms of oral tolerance induction to food and aeroallergens in human tonsils. Methods: Tonsil allergen-specific FOXP31 regulatory T (Treg)cells, plasmacytoid dendritic cells (pDCs), and myeloid dendritic cells were characterized by flow cytometry and suppressive assays. Intracellular staining, [3H]-thymidine incorporation, and carboxy-fluorescein succinimidyl ester dilution experiments were performed. Tonsil biopsies were analyzed by confocal microscopy. Results: CD41FOXP31 Treg cells and pDCs constitute important T- and dendritic cell–compartments in palatine and lingual tonsils. Tonsil pDCs have the ability to generate functional CD41CD251CD1272FOXP31 Treg cells with suppressive property from naive T cells. CD41FOXP31 Treg cells proliferate and colocalize with pDCs in vivo in T-cell areas of lingual and palatine tonsils. Tonsil T cells did not proliferate to common food and aeroallergens. Depletion of FOXP31 Treg cells enables the allergen-induced proliferation of tonsil T cells, indicating an active role of Treg cells in allergen-specific T-cell unresponsiveness. High numbers of major birch pollen allergen, Bet v 1–specific CD41FOXP31 Treg cells, are identified in human tonsils compared with peripheral blood. A positive correlation between the percentages of FOXP31 Treg cells and pDCs is observed in tonsils from nonatopic individuals. Conclusion: Functional allergen-specific Treg cells are identified both in lingual and in palatine tonsils. (J Allergy Clin Immunol 2011 ; nnn:nnn-nnn.)

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina



POVEZANOST RADA


Projekti:
065-0650235-0145 - Istraživanje međuodnosa alergije i infekcije u rinosinuitisu i nosnoj polipozi (Kalogjera, Livije, MZOS ) ( POIROT)

Ustanove:
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Palomares, Oscar; Ruckert, Beate; Jartti, T; Kucuksezer, Umut C; Puhakka, T; Gomez, E; Fahrner HB; Speiser, A; Jung, A; Kwok, WW et al.
Induction and maintenance of allergen-specific FOXP31 Treg cells in human tonsils as potential first-line organs of oral tolerance // Journal of allergy and clinical immunology (2011) (ostalo, prihvaćen)
Palomares, O., Ruckert, B., Jartti, T., Kucuksezer, U., Puhakka, T., Gomez, E., Fahrner HB, Speiser, A., Jung, A. & Kwok, W. (2011) Induction and maintenance of allergen-specific FOXP31 Treg cells in human tonsils as potential first-line organs of oral tolerance. Prihvaćen za objavljivanje u Journal of allergy and clinical immunology. [Preprint].
@unknown{unknown, year = {2011}, keywords = {Immune tolerance, tonsils, allergen-specific Treg cells, }, journal = {Journal of allergy and clinical immunology}, title = {Induction and maintenance of allergen-specific FOXP31 Treg cells in human tonsils as potential first-line organs of oral tolerance}, keyword = {Immune tolerance, tonsils, allergen-specific Treg cells, } }
@unknown{unknown, year = {2011}, keywords = {Immune tolerance, tonsils, allergen-specific Treg cells, }, journal = {Journal of allergy and clinical immunology}, title = {Induction and maintenance of allergen-specific FOXP31 Treg cells in human tonsils as potential first-line organs of oral tolerance}, keyword = {Immune tolerance, tonsils, allergen-specific Treg cells, } }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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