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Two intertwined facets of adherent membranes : Membrane roughness and correlations between ligand-receptors bonds


Reister, Ellen; Bihr, Timo; Smith, Ana-Sunčana;
Two intertwined facets of adherent membranes : Membrane roughness and correlations between ligand-receptors bonds // New journal of physics, 13 (2011), 025003-1 doi:10.1088/1367-2630/13/2/025003 (međunarodna recenzija, članak, znanstveni)


Naslov
Two intertwined facets of adherent membranes : Membrane roughness and correlations between ligand-receptors bonds

Autori
Reister, Ellen ; Bihr, Timo ; Smith, Ana-Sunčana ;

Izvornik
New journal of physics (1367-2630) 13 (2011); 025003-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adherent membranes; Langevin simulation

Sažetak
We study equilibrium fluctuations of adherent membranes by means of Langevin simulations in the case when the interaction of the membrane with the substrate is twofold: a non-specific homogeneous harmonic potential is placed at large distances, whereas discrete ligand–receptor interactions occur at short distances from the flat substrate. We analyze the correlations between neighboring ligand–receptor bonds in a regime of relatively strong membrane fluctuations. By comparison with the random distribution of bonds, we find that the correlations between the bonds are always positive, suggesting spontaneous formation of domains. The equilibrium roughness of the membrane is then determined by fluctuations in the number density of bonds within the domains. Furthermore, we show that the excess number of bonds arising due to correlations and the instantaneous roughness of the membrane both follow master curves that depend only on the instantaneous bond density and not on the intrinsic binding strength of the ligand–receptor pair. The master curves show identical trends, further corroborating the link between membrane roughness and bond correlations.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA


Projekt / tema
098-1191344-2860 - Proučavanje biomakromolekula računalnim metodama i razvoj novih algoritama (Sanja Tomić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Ana Sunčana Smith, (280014)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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