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Pregled bibliografske jedinice broj: 547772

The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy


Gržetić-Lenac, Renata; Merlak, Maja; Balog, Tihomir; Markušić, Vedran; Dekaris, Iva
The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy // Collegium antropologicum, 35 (2011), S2; 171-173 (međunarodna recenzija, članak, znanstveni)


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Naslov
The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy

Autori
Gržetić-Lenac, Renata ; Merlak, Maja ; Balog, Tihomir ; Markušić, Vedran ; Dekaris, Iva

Izvornik
Collegium antropologicum (0350-6134) 35 (2011), S2; 171-173

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cornea; bullous keratopathy; IL-1; TNF; VEGF

Sažetak
Bullous keratopathy (BK) is a chronic corneal edema with or without subepithelial bullae as a result of a loss of the endothelial cells. 15 patients with BK after cataract surgery with intraocular lens implantation, due to Fuchs dystrophy (n=3) or corneal endothelial trauma (n=12) were included in the study. All patients were treated by amniotic membrane transplantation (AMT). Corneal epithelial cells in patients suffering from BK secreted 3.91±3.09 pg/mL of IL-1 alpha, 4446±16.8 pg/mL of TNF and 81.43±37.81 pg/mL of VEGF-I. Levels of all 3 investigated cytokines were significantly higher as compared to controls (p<0.005). Amniotic membranes that were used to treat investigated patients contained 638.98±613.98 pg/mL of IL-1ra, 0.026±0.009 pg/mL of sTNF and 81.39±21.01 pg/mL of VEGF-R. Beneficial clinical effect of the AMT in treating BK could be explained by its natural production of pro-inflammatory cytokine antagonists such as IL-ra, sTNF antagonist and VEGF-R.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0000000-0222 - Imunologija oka (Dekaris, Iva, MZOS ) ( POIROT)
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Balog, Tihomir, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Tihomir Balog (autor)

Avatar Url Renata Gržetić-Lenac (autor)

Avatar Url Maja Merlak (autor)

Avatar Url Iva Dekaris (autor)

Poveznice na cjeloviti tekst rada:

Hrčak

Citiraj ovu publikaciju:

Gržetić-Lenac, Renata; Merlak, Maja; Balog, Tihomir; Markušić, Vedran; Dekaris, Iva
The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy // Collegium antropologicum, 35 (2011), S2; 171-173 (međunarodna recenzija, članak, znanstveni)
Gržetić-Lenac, R., Merlak, M., Balog, T., Markušić, V. & Dekaris, I. (2011) The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy. Collegium antropologicum, 35 (S2), 171-173.
@article{article, year = {2011}, pages = {171-173}, keywords = {Cornea, bullous keratopathy, IL-1, TNF, VEGF}, journal = {Collegium antropologicum}, volume = {35}, number = {S2}, issn = {0350-6134}, title = {The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy}, keyword = {Cornea, bullous keratopathy, IL-1, TNF, VEGF} }
@article{article, year = {2011}, pages = {171-173}, keywords = {Cornea, bullous keratopathy, IL-1, TNF, VEGF}, journal = {Collegium antropologicum}, volume = {35}, number = {S2}, issn = {0350-6134}, title = {The Expression of Interleukin-1 alpha, TNF and VEGF in Corneal Cells of Patients with Bullous Keratopathy}, keyword = {Cornea, bullous keratopathy, IL-1, TNF, VEGF} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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