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Pregled bibliografske jedinice broj: 547349

Comparison of evening and morning dosing of travoprost 0, 004%/timolol 0, 5% fixed combination in 6 month period


Popović Suić, Smiljka; Novak Lauš, Katia; Maričić Došen, Vukosava; Ekert, Miroslav; Mandić, Zdravko; Bojić, Lovre
Comparison of evening and morning dosing of travoprost 0, 004%/timolol 0, 5% fixed combination in 6 month period // Collegium antropologicum, 34 (2010), 3; 847-852 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 547349 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Comparison of evening and morning dosing of travoprost 0, 004%/timolol 0, 5% fixed combination in 6 month period
(Comparison of evening and morning dosing travoprost0, 004%/timolol0, 5% fixed combination in 6 month petriod)

Autori
Popović Suić, Smiljka ; Novak Lauš, Katia ; Maričić Došen, Vukosava ; Ekert, Miroslav ; Mandić, Zdravko ; Bojić, Lovre

Izvornik
Collegium antropologicum (0350-6134) 34 (2010), 3; 847-852

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
fixed combination ; travoprost ; timolol

Sažetak
An open label, multi-center, 6 months observational study of new fixed combination (travoprost 0.004%/timolol 0.5%), in order to evaluate both efficacy (intraocular pressure lowering) and tolerability (patient and investigator satisfaction) of two dosing regimens--evening (PM) and morning (AM). After screening for enrollment, to 40 patients (79 eyes with primary open angle glaucoma or ocular hypertension), new fixed combination travoprost 0.004%/timolol 0.5% was prescribed once a day in the evening (PM). Patients were enrolled according to each investigator decision on indication for travoprost 0.004%/timolol 0.5% fixed combination once a day, without washout period after previous medication. Intraocular pressure was measured at 9 AM at all time control points: at baseline, after 1 month, after 3 months and after 6 month. After 1 month, screening for nonresponders (criteria: 20% intraocular pressure lowering) and subjects with major side effects was performed. At second control visit, after 3 months PM dosing, intraocular pressure was measured and patients were instructed to continue once a day the same medication, but in the morning (AM) for consequent 3 months. After 1 month, reduction in mean intraocular pressure value was 21.66%. At the visit after 3 month, the mean intraocular pressure was 15.67 +/- 2.17 mm Hg (reduction 21.14%). 3 month after dosing regimen changed to AM (6 month after beginning of travoprost 0.004%/timolol 0.5% combination therapy), reduction in intraocular pressure value was 19.86%. The differences (mean +/- standard deviation) in intraocular pressure values after 1, 3 and 6 month were all highly statistically significant compared to baseline values. The tolerability was evaluated in five steps (Likert scale) ranging from unsatisfactory to excellent by both patient and investigator--taken at 3 and 6 month control visit. 95% of patients and 100% of investigators were satisfied with the possibility of choosing dosing regimen for travoprost 0.004%/timolol 0.5% fixed combination. Travoprost 0.004%/timolol 0.5% fixed combination proved sufficient intraocular pressure control dosed either PM or AM with no statistically significant difference between two dosing regimens. Possibility to choose between two dosing regimens gives each practitioner additional reassurance that glaucoma therapy will be individualised to needs of each patient.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC "Sestre Milosrdnice"

Citiraj ovu publikaciju

Popović Suić, Smiljka; Novak Lauš, Katia; Maričić Došen, Vukosava; Ekert, Miroslav; Mandić, Zdravko; Bojić, Lovre
Comparison of evening and morning dosing of travoprost 0, 004%/timolol 0, 5% fixed combination in 6 month period // Collegium antropologicum, 34 (2010), 3; 847-852 (međunarodna recenzija, članak, znanstveni)
Popović Suić, S., Novak Lauš, K., Maričić Došen, V., Ekert, M., Mandić, Z. & Bojić, L. (2010) Comparison of evening and morning dosing of travoprost 0, 004%/timolol 0, 5% fixed combination in 6 month period. Collegium antropologicum, 34 (3), 847-852.
@article{article, year = {2010}, pages = {847-852}, keywords = {fixed combination, travoprost, timolol}, journal = {Collegium antropologicum}, volume = {34}, number = {3}, issn = {0350-6134}, title = {Comparison of evening and morning dosing of travoprost 0, 004\%/timolol 0, 5\% fixed combination in 6 month period}, keyword = {fixed combination, travoprost, timolol} }
@article{article, year = {2010}, pages = {847-852}, keywords = {fixed combination, travoprost, timolol}, journal = {Collegium antropologicum}, volume = {34}, number = {3}, issn = {0350-6134}, title = {Comparison of evening and morning dosing travoprost0, 004\%/timolol0, 5\% fixed combination in 6 month petriod}, keyword = {fixed combination, travoprost, timolol} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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