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Pregled bibliografske jedinice broj: 546955

Vitamin D and PTH serum levels and their relationship with some measures of disease activity in a group of patients with established psoriatic arthritis


Grazio, Simeon; Babić Naglić, Đurđa; Anić, Branimir; Grubišić, Frane; Bobek, Dubravka; Skala, Hana; Bakula, Marija; Tešija Kuna, Andrea; Vrkić, Nada; Ćurković, Božidar
Vitamin D and PTH serum levels and their relationship with some measures of disease activity in a group of patients with established psoriatic arthritis // 14th Mediterranean Congress of Rheumatology : Abstract Book / Minisola, Giovanni ; Matucci Cerinic, Marco (ur.).
Pavia: Societa Italiana di Reumatologia, 2011. str. 23-23 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Vitamin D and PTH serum levels and their relationship with some measures of disease activity in a group of patients with established psoriatic arthritis

Autori
Grazio, Simeon ; Babić Naglić, Đurđa ; Anić, Branimir ; Grubišić, Frane ; Bobek, Dubravka ; Skala, Hana ; Bakula, Marija ; Tešija Kuna, Andrea ; Vrkić, Nada ; Ćurković, Božidar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
14th Mediterranean Congress of Rheumatology : Abstract Book / Minisola, Giovanni ; Matucci Cerinic, Marco - Pavia : Societa Italiana di Reumatologia, 2011, 23-23

Skup
Mediterranean Congress of Rheumatology (14 ; 2011)

Mjesto i datum
Sorrento, Italija, 06.-08.10.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Vitamin D; parathyroid hormone; psoriatic arthritis; functional status; illness index severity

Sažetak
It is well established that lower levels of vitamin D are associated with higher disease activity in rheumatoid arthritis, SLE and ankylosing spondylitis. From our investigation that was designed to evaluate the correlation between vitamin D serum level and clinical measures of disease activity/severity in patients with psoriatic arthritis and rheumatoid arthritis, (controls were subjects without inflammatory rheumatic conditions), here we present the results for psoriatic arthritis. Thirty-eight consecutive patients (19 men, 19 women), aged 56.610.18 years, with psoriatic arthritis (duration of the disease 180.13102.84 months) were enrolled, during a winter period (Jan, Feb, Mar) from the three University rheumatologic centres in Zagreb (Croatia). Controls were 29 patients of mean age 68.246.68 years, with non-inflammatory osteoartricular conditions. Apart from demographic data, clinical and laboratory measurements of disease activity and severity were collected in patients with PsA, while circulating concentration of 25(OH)D3 and PTH were determined in both groups using ECL- based immunoassay. Level of significance was set up at 0.05. Results. In subjects with PsA vitamin serum level was 59.376.32 nmol/L and was significantly higher than in controls (32.9920.1 nmol/L). PTH serum level for both groups were within normal range with no difference between groups (PsA patients 4.973.06 pmol/L ; controls 6.142.37 pmol/L). There was a significant negative correlation between level of serum vitamin D in controls with serum PTH and age. As for parameters of disease activity we found a significant positive correlation between vitamin D level with ESR and CRP (after adjusting for age and hours of weekly sun exposure). Negative correlation was found between PTH serum level and the duration of morning stiffness. In our cross-sectional study, patients with PsA, with high level of disease activity, had sufficient level of circulating 25(OH)D3 which was significantly higher than in subject with no inflammatory rheumatic disease. The difference might be explained by the fact that controls were older and had significantly correlation of serum vitamin D level with age. Normal levels of serum PTH were found in both groups. Correlations of vitamin D level with some laboratory, although not clinical measures of disease activity were observed, while PTH correlated only with one clinical variable.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
108-1081874-2419 - Epidemiološka obilježja sistemskog eritemskog lupusa u Hrvatskoj (Nada Čikeš, )
134-0000000-3531 - Psorijatični artritis - epidemiologija i čimbenici rizika progresije (Simeon Grazio, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb,
Zdravstveno veleučilište, Zagreb,
Medicinski fakultet, Osijek