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Pregled bibliografske jedinice broj: 546938

Safety and efficacy of monotherapy change to fixed combination (travoprost 0.004%/timolol 0.5%) in 6 months follow up period


Mandić, Zdravko; Novak-Lauš, Katia; Bojić, Lovre; Popović-Suić, Smiljka; Ekert, M; Dosen, VM; ; Pelcić, Goran; Clementi, D; Dobutović, D et al.
Safety and efficacy of monotherapy change to fixed combination (travoprost 0.004%/timolol 0.5%) in 6 months follow up period // Acta clinica Croatica, 49 (2010), 4; 411-419 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 546938 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Safety and efficacy of monotherapy change to fixed combination (travoprost 0.004%/timolol 0.5%) in 6 months follow up period

Autori
Mandić, Zdravko ; Novak-Lauš, Katia ; Bojić, Lovre ; Popović-Suić, Smiljka ; Ekert, M ; Dosen, VM ; ; Pelcić, Goran ; Clementi, D ; Dobutović, D ; Biuk, D ; Iveković, Renata ; Kovacić, Z ; Pavan, J ; Susić, Nikola ; Geser, MZ ; Krolo, Iva ; Barišić, Freja ; Jurić-Miletić, A ; Dogan, KK ; Tomić, M ; Kovacević S.

Izvornik
Acta clinica Croatica (0353-9466) 49 (2010), 4; 411-419

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
glaucoma ; travanoprost

Sažetak
PURPOSE: To assess the safety and efficacy of changing antiglaucoma therapy to the travoprost 0.004%/timolol 0.5% (TTFC) fixed combination from previous monotherapies. METHODS: Prospective, open-label, observational, multicenter cohort. A change was done from prior monotherapy at day 0 to TTFC dosed once a day, regardless in the evening or in the morning, without washout period. Active evaluation of systemic and local tolerability (adverse events), and efficacy. i.e., intraocular pressure (IOP) lowering was done at control 1 (day 30), control 2 (day 90) and control 3 (day 120). RESULTS: 40/155/170 patients (79/309/339 eyes) completed the study (120 days/ 90 days/baseline, respectfully). At control 1 excluded were patients with low tolerability (severe hyperemia (6 patients), discomfort (4), chest pain (1)) and non responders (IOP lowering less than 15% from baseline IOP or target IOP >18 mmHg (4 patients)). Mean IOP at control 1 was 15.92 +/- 1.85 mm Hg (21.66% reduction) for 155 patients (non responders excluded), at control 2 was for 155 patients 15.67 +/- 2.17 mm Hg (21.14% reduction), and at control 3 for 40 patients 16.28 +/- 1.59 mm Hg (19.86% reduction). At control 2 analysis of IOP reduction by 4 groups of previous monotherapy (timolol 0, 5% (N = 33/66), latanoprost 0.005% (N = 49/98), betaxolol 0.5% (N = 30/60), and travoprost 0.004% (N = 43/85) was performed. 40 patients/79 eyes endured to control 3 (after day 90 free samples were not available for all patients). Analysis of IOP reduction by 4 groups of previous monotherapy medications was performed (timolol 0.5% (N = 7/14), latanoprost 0.005% (N = 14/28), betaxolol 0.5% (N = 7/14), travoprost 0.004% (N = 12/23)). CONCLUSIONS: Changing patients from prior monotherapy to TTFC can provide on average a further reduction in IOP, while demonstrating a favorable safety profile.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
134-1340236-0181 - Distiroidna orbitopatija i glaukom (Iveković, Renata, MZOS ) ( POIROT)
134-1340236-0185 - Rano otkrivanje primarnog glaukoma otvorenog kuta (Novak-Lauš, Katia, MZOS ) ( POIROT)

Ustanove:
KBC "Sestre Milosrdnice"

Citiraj ovu publikaciju

Mandić, Zdravko; Novak-Lauš, Katia; Bojić, Lovre; Popović-Suić, Smiljka; Ekert, M; Dosen, VM; ; Pelcić, Goran; Clementi, D; Dobutović, D et al.
Safety and efficacy of monotherapy change to fixed combination (travoprost 0.004%/timolol 0.5%) in 6 months follow up period // Acta clinica Croatica, 49 (2010), 4; 411-419 (međunarodna recenzija, članak, znanstveni)
Mandić, Z., Novak-Lauš, K., Bojić, L., Popović-Suić, S., Ekert, M., Dosen, V., , Pelcić, G., Clementi, D. & Dobutović, D. (2010) Safety and efficacy of monotherapy change to fixed combination (travoprost 0.004%/timolol 0.5%) in 6 months follow up period. Acta clinica Croatica, 49 (4), 411-419.
@article{article, year = {2010}, pages = {411-419}, keywords = {glaucoma, travanoprost}, journal = {Acta clinica Croatica}, volume = {49}, number = {4}, issn = {0353-9466}, title = {Safety and efficacy of monotherapy change to fixed combination (travoprost 0.004\%/timolol 0.5\%) in 6 months follow up period}, keyword = {glaucoma, travanoprost} }
@article{article, year = {2010}, pages = {411-419}, keywords = {glaucoma, travanoprost}, journal = {Acta clinica Croatica}, volume = {49}, number = {4}, issn = {0353-9466}, title = {Safety and efficacy of monotherapy change to fixed combination (travoprost 0.004\%/timolol 0.5\%) in 6 months follow up period}, keyword = {glaucoma, travanoprost} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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