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Pregled bibliografske jedinice broj: 546484

Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease


Herceg-Čavrak, Vesna; Ahel, Vladimir; Batinica, Maja; Matec, Lana; Kardoš, Danijel
Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease // Collegium antropologicum, 35 (2011), 2; 389-395 (međunarodna recenzija, članak, znanstveni)


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Naslov
Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease

Autori
Herceg-Čavrak, Vesna ; Ahel, Vladimir ; Batinica, Maja ; Matec, Lana ; Kardoš, Danijel

Izvornik
Collegium antropologicum (0350-6134) 35 (2011), 2; 389-395

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
anthracyclines ; arteries ; drug effects ; child ; neoplasms ; drug therapy ; oscillometry

Sažetak
Survivors of childhood cancer have a significantly higher late morbidity and mortality from cardiovascular diseases. The aim of this study was to determine whether anthracyclines used in childhood could increase arterial stiffness, a well-known independent predictor of cardiovascular diseases. The study included 53 children and adolescents aged 6-20 years having completed anthracycline treatment for a malignant disease according to various protocols at least a year before. The patients were free from clinical or laboratory signs of the underlying disease or cardiac disease. Control group consisted of 45 age- and sex- matched healthy children. Arterial stiffness was determined by measuring aortic pulse wave velocity (PWVao) using oscillometric method (Arteriograph TensioMed device). PWVao value was significantly increased (6.24±1.34 m/s vs. 5.42±0.69 m/s ; p<0.001) in patients having received anthracyclines as compared to control group. Increased arterial stiffness was present irrespective of the following parameters: age, sex, body mass index, systolic and diastolic blood pressure, mean arterial pressure and heart rate. It is possible that the effect of anthracycline on increased cardiovascular morbidity and mortality in long-term childhood cancer survivors is associated not only with cardiotoxicity, but also with increased arterial stiffness.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
072-0000000-0249 - Longitudinalna studija o rastu i razvoju djece predškolske dobi u Hrvatskoj (Grgurić, Josip, MZOS ) ( POIROT)

Ustanove:
Klinika za dječje bolesti Medicinskog fakulteta,
Sveučilište Libertas

Profili:

Avatar Url Vesna Herceg-Čavrak (autor)

Avatar Url Maja Batinica (autor)

Citiraj ovu publikaciju

Herceg-Čavrak, Vesna; Ahel, Vladimir; Batinica, Maja; Matec, Lana; Kardoš, Danijel
Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease // Collegium antropologicum, 35 (2011), 2; 389-395 (međunarodna recenzija, članak, znanstveni)
Herceg-Čavrak, V., Ahel, V., Batinica, M., Matec, L. & Kardoš, D. (2011) Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease. Collegium antropologicum, 35 (2), 389-395.
@article{article, year = {2011}, pages = {389-395}, keywords = {anthracyclines, arteries, drug effects, child, neoplasms, drug therapy, oscillometry}, journal = {Collegium antropologicum}, volume = {35}, number = {2}, issn = {0350-6134}, title = {Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease}, keyword = {anthracyclines, arteries, drug effects, child, neoplasms, drug therapy, oscillometry} }
@article{article, year = {2011}, pages = {389-395}, keywords = {anthracyclines, arteries, drug effects, child, neoplasms, drug therapy, oscillometry}, journal = {Collegium antropologicum}, volume = {35}, number = {2}, issn = {0350-6134}, title = {Increased Arterial Stiffness in Children Treated with Anthracyclines for Malignant Disease}, keyword = {anthracyclines, arteries, drug effects, child, neoplasms, drug therapy, oscillometry} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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