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Pregled bibliografske jedinice broj: 546000

Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases


Sučić, Mirna; Boban, Dubravka; Marković-Glamočak, Mirjana; Jakić-Razumović, Jasminka; Vrbanec, Damir; Ries, Sunčica; Gjadrov-Kuveždić, Koraljka; Čobanov, Ana-Marija; Podolski, Paula; Martinović, Igor et al.
Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases // Breast, 12 (2003), 1; 51-57 doi:10.1016/S0960-9776(02)00281-3 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 546000 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases

Autori
Sučić, Mirna ; Boban, Dubravka ; Marković-Glamočak, Mirjana ; Jakić-Razumović, Jasminka ; Vrbanec, Damir ; Ries, Sunčica ; Gjadrov-Kuveždić, Koraljka ; Čobanov, Ana-Marija ; Podolski, Paula ; Martinović, Igor ; Erak, Vigo ; Budišić, Zdenko ; Ivrlač, Radojko ; Unušić, Joško

Izvornik
Breast (0960-9776) 12 (2003), 1; 51-57

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
breast carcinoma ; cyclooxigenase ; immunocytochemistry

Sažetak
Numerous studies have demonstrated that the levels of cyclooxygenase (COX), the enzyme that catalyzes the conversion of arachidonic acid to prostaglandin H(2), and of prostaglandins are higher in various tumors and cells during inflammation than in normal tissues. The aim of the present study was to analyze whether COX-2 isoform expression was noticeably higher in fine-needle aspirates (FNA) from breast carcinoma than in FNA from fibroadenoma and fibrocystic breast tissue. COX-2 expression was detected by immunocytochemical (IC) staining and was analyzed by microscopic scoring and computer gray-scale analysis. Evaluation of COX-2 IC positivity in FNA from three groups of patients (nine with breast carcinoma, nine with fibroadenoma, eight with fibrocystic breasts) revealed high COX-2 IC positivity in the majority of patients with breast carcinoma and low or absent COX-2 IC positivity in patients with fibrocystic breast changes. In addition, low or medium COX-2 IC positivity was found in the majority of patients with fibroadenoma, only three of these patients having high COX-2 IC positivity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
0098107
0108288
129-0000000-3385 - Citološki pokazatelji proliferacije stanica (Sučić, Mirna, MZOS ) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinička bolnica "Sveti Duh"

Citiraj ovu publikaciju

Sučić, Mirna; Boban, Dubravka; Marković-Glamočak, Mirjana; Jakić-Razumović, Jasminka; Vrbanec, Damir; Ries, Sunčica; Gjadrov-Kuveždić, Koraljka; Čobanov, Ana-Marija; Podolski, Paula; Martinović, Igor et al.
Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases // Breast, 12 (2003), 1; 51-57 doi:10.1016/S0960-9776(02)00281-3 (međunarodna recenzija, članak, znanstveni)
Sučić, M., Boban, D., Marković-Glamočak, M., Jakić-Razumović, J., Vrbanec, D., Ries, S., Gjadrov-Kuveždić, K., Čobanov, A., Podolski, P. & Martinović, I. (2003) Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases. Breast, 12 (1), 51-57 doi:10.1016/S0960-9776(02)00281-3.
@article{article, year = {2003}, pages = {51-57}, DOI = {10.1016/S0960-9776(02)00281-3}, keywords = {breast carcinoma, cyclooxigenase, immunocytochemistry}, journal = {Breast}, doi = {10.1016/S0960-9776(02)00281-3}, volume = {12}, number = {1}, issn = {0960-9776}, title = {Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases}, keyword = {breast carcinoma, cyclooxigenase, immunocytochemistry} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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