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Psychiatric Disorders in Patients with Cushing's Disease Before and After Neurosurgery (CROSBI ID 177525)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Gnjidić, Živko ; Karlović, Dalibor ; Buljan, Danijel ; Malenica, Maša ; Kovak-Mufić, Ana ; Kostanjšak, Lidija Psychiatric Disorders in Patients with Cushing's Disease Before and After Neurosurgery // Turk psikiyatri dergisi, 22 (2011), 1; 35-39

Podaci o odgovornosti

Gnjidić, Živko ; Karlović, Dalibor ; Buljan, Danijel ; Malenica, Maša ; Kovak-Mufić, Ana ; Kostanjšak, Lidija

engleski

Psychiatric Disorders in Patients with Cushing's Disease Before and After Neurosurgery

Objective: ACTH secreting pituitary adenoma leads to hypercortisolism and is a consequence of the development of Cushing's disease which is connected to different psychiatric disturbances. The aim of this paper was to examine which psychiatric disorders were present and to monitor general psychiatric condition of the patients with Cushing’s disease over a two-year period. The second aim of the study was to examine the correlations between the duration of Cushing’s disease and severity of psychiatric condition measured by psychiatric rating scales. Method: Research was conducted on 39 patients with Cushing’s disease who had an operation of ACTH secreting pituitary adenoma. All patients were operated using the standard microsurgery technique of transsphenoid approach. ACTH secreting pituitary adenoma was confirmed by immunohistochemistry in all patients. The patients’ psychiatric condition was monitored by the Clinical Global Impression scale (CGI) and ICD 10 diagnostic criteria in three points of time: prior to surgery, six months, and two years after surgery. Results: The patients with Cushing’s disease showed a statistically significant improvement in their psychiatric condition which was measured by CGI scale both six months and two years after surgery (Friedman test=70.886 ; df=2 ; p<0.01). There was no significant correlation between the duration of Cushing’s disease and severity of psychiatric status measured by CGI prior to surgery (Spearman’s correlation=0.133, p=0.419), six months after surgery (Spearman’s correlation=0.110, p=0.504) and two years after surgery (Spearman’s correlation=0.073, p=0.66). Conclusion: Patients with Cushing’s disease had significant psychiatric disturbances that withdrew after surgery. There was no significant correlation between the duration of Cushing’s disease and severity of psychiatric status.

Cushing’s disease; psychiatric disorders; longitudinal follow up; neurosurgery

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Podaci o izdanju

22 (1)

2011.

35-39

objavljeno

1300-2163

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost