Liver involvement during influenza infection : perspective on the 2009 influenza pandemic (CROSBI ID 177434)
Prilog u časopisu | kratko priopćenje | međunarodna recenzija
Podaci o odgovornosti
Papić, Neven ; Pangerčić, Ana ; Vargović, Martina ; Baršić, Bruno ; Vince, Adriana ; Kuzman, Ilija
engleski
Liver involvement during influenza infection : perspective on the 2009 influenza pandemic
Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.
Alanine aminotransferase; H1N1; hypoxia; influenza; liver; systemic inflammatory response
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Podaci o izdanju
6 (3)
2011.
e2-e5
objavljeno
1750-2640
10.1111/j.1750-2659.2011.00287.x
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita