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Liver involvement during influenza infection : perspective on the 2009 influenza pandemic


Papić, Neven; Pangerčić, Ana; Vargović, Martina; Baršić, Bruno; Vince, Adriana; Kuzman, Ilija
Liver involvement during influenza infection : perspective on the 2009 influenza pandemic // Influenza and other respiratory viruse, 6 (2011), 3; e2-e5 doi:10.1111/j.1750-2659.2011.00287.x (međunarodna recenzija, kratko priopcenje, znanstveni)


Naslov
Liver involvement during influenza infection : perspective on the 2009 influenza pandemic

Autori
Papić, Neven ; Pangerčić, Ana ; Vargović, Martina ; Baršić, Bruno ; Vince, Adriana ; Kuzman, Ilija

Izvornik
Influenza and other respiratory viruse (1750-2640) 6 (2011), 3; E2-e5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
Alanine aminotransferase; H1N1; hypoxia; influenza; liver; systemic inflammatory response

Sažetak
Elevation of liver transaminase levels is a frequent observation during systemic infections. The aim of our study was to investigate liver damage during pandemic 2009 influenza A/H1N1 infection in comparison with seasonal influenza. Serum levels of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transpeptidase (GGT) were significantly higher in patients with pandemic influenza compared to seasonal influenza, which was strongly correlated with hypoxia. Moreover, a positive correlation between C-reactive protein and serum GGT, alkaline phosphatase, and lactate dehydrogenase was noticed. Our findings support the hypothesis that the pandemic 2009 influenza A/H1N1 is an illness with a significant immune response to infection leading to hepatocellular injury.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
108-0000000-3491 - ISTRAŽIVANJE ETIOLOGIJE I PATOGENEZE PNEUMONIJA (Ilija Kuzman, )
108-1080002-0102 - Procjena potrebe i učinkovitosti liječenja teških infekcija u JIM (Bruno Baršić, )
143-0000000-0117 - Imunopatogeneza hepatitisa B i C (Adriana Vince, )

Ustanove
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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