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Pregled bibliografske jedinice broj: 54469

Hypertension of beta-adducin-deficient mice.


Marro, Martin L.; Scremin, Oscar U.; Jordan Maria C.; Huynh, Ly; Porro, Fabiola; Roos, Kenneth P.; Gajović, Srećko; Baralle, Francisco E.; Muro, Andres F.
Hypertension of beta-adducin-deficient mice. // Hypertension, 36 (2000), 449-453 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 54469 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Hypertension of beta-adducin-deficient mice.

Autori
Marro, Martin L. ; Scremin, Oscar U. ; Jordan Maria C. ; Huynh, Ly ; Porro, Fabiola ; Roos, Kenneth P. ; Gajović, Srećko ; Baralle, Francisco E. ; Muro, Andres F.

Izvornik
Hypertension (0194-911X) 36 (2000); 449-453

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genetic hypertension; adducin; mouse; knockout; echocardiography; cytoskeleton; telemetry; electrocardiography

Sažetak
Polymorphic variants of the cytoskeletal protein adducin have been associated with hypertension in humans and rats. However, the direct role of this protein in modulating arterial blood pressure has never been demonstrated. To assess the effect of beta-adducin on blood pressure, a beta-adducin–deficient mouse strain (-/-) was studied and compared with wild-type controls (+/+). Aortic blood pressure was measured in nonanesthetized, freely moving animals with the use of telemetry implants. It is important to note that these mice have at least 98% of C57Bl/6 genetic background, with the only difference from wild-type animals being the beta-adducin mutation. We found statistically significant higher levels of systolic blood pressure (mm Hg) (mean+-SE values: -/-: 126.94+-1.14, n=55; +/+: 108.06+-2.34, n=56; P<0.0001), diastolic blood pressure (-/-: 83.54+-1.07; +/+: 74.8762.23; P<0.005), and pulse blood pressure (-/-: 43.32+-1.10; +/+: 33.19+-1.96; P<0.001) in beta-adducin–deficient mice. Western blot analysis showed that as a result of the introduced genetic modification, beta-adducin was not present in heart protein extracts from -/- mice. Consequently, this deficiency produced a sharp decrease of alpha-adducin and a lesser reduction in gamma-adducin levels. However, we found neither cardiac remodeling nor modification of the heart function in these animals. This is the first report showing direct evidence that hypertension is triggered by a mutation in the adducin gene family.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108117

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Srećko Gajović (autor)


Citiraj ovu publikaciju:

Marro, Martin L.; Scremin, Oscar U.; Jordan Maria C.; Huynh, Ly; Porro, Fabiola; Roos, Kenneth P.; Gajović, Srećko; Baralle, Francisco E.; Muro, Andres F.
Hypertension of beta-adducin-deficient mice. // Hypertension, 36 (2000), 449-453 (međunarodna recenzija, članak, znanstveni)
Marro, M., Scremin, O., Jordan Maria C., Huynh, L., Porro, F., Roos, K., Gajović, S., Baralle, F. & Muro, A. (2000) Hypertension of beta-adducin-deficient mice.. Hypertension, 36, 449-453.
@article{article, author = {Marro, Martin L. and Scremin, Oscar U. and Huynh, Ly and Porro, Fabiola and Roos, Kenneth P. and Gajovi\'{c}, Sre\'{c}ko and Baralle, Francisco E. and Muro, Andres F.}, year = {2000}, pages = {449-453}, keywords = {genetic hypertension, adducin, mouse, knockout, echocardiography, cytoskeleton, telemetry, electrocardiography}, journal = {Hypertension}, volume = {36}, issn = {0194-911X}, title = {Hypertension of beta-adducin-deficient mice.}, keyword = {genetic hypertension, adducin, mouse, knockout, echocardiography, cytoskeleton, telemetry, electrocardiography} }
@article{article, author = {Marro, Martin L. and Scremin, Oscar U. and Huynh, Ly and Porro, Fabiola and Roos, Kenneth P. and Gajovi\'{c}, Sre\'{c}ko and Baralle, Francisco E. and Muro, Andres F.}, year = {2000}, pages = {449-453}, keywords = {genetic hypertension, adducin, mouse, knockout, echocardiography, cytoskeleton, telemetry, electrocardiography}, journal = {Hypertension}, volume = {36}, issn = {0194-911X}, title = {Hypertension of beta-adducin-deficient mice.}, keyword = {genetic hypertension, adducin, mouse, knockout, echocardiography, cytoskeleton, telemetry, electrocardiography} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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