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Pregled bibliografske jedinice broj: 544263

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol


Surakka, I.; Isaacs, A.; Karssen, L.C.; Rudan, Igor; ...; Ripatti, S.
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol // Plos genetics, 7 (2011), 1002333-1 (međunarodna recenzija, članak, znanstveni)


Naslov
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Autori
Surakka, I. ; Isaacs, A. ; Karssen, L.C. ; Rudan, Igor ; ... ; Ripatti, S.

Izvornik
Plos genetics (1553-7390) 7 (2011); 1002333-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Gene; wiast-to-hip

Sažetak
Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene-environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32, 225). We collected 8 further cohorts (N = 17, 102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on total cholesterol (TC) with a combined P-value of 4.79×10(-9). There were two potential candidate genes in the region, PCDH7 and CCKAR, with differential expression levels for rs6448771 genotypes in adipose tissue. The effect of WHR on TC was strongest for individuals carrying two copies of G allele, for whom a one standard deviation (sd) difference in WHR corresponds to 0.19 sd difference in TC concentration, while for A allele homozygous the difference was 0.12 sd. Our findings may open up possibilities for targeted intervention strategies for people characterized by specific genomic profiles. However, more refined measures of both body-fat distribution and metabolic measures are needed to understand how their joint dynamics are modified by the newly found locus

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
The ENGAGE Consortium



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )

Ustanove
Medicinski fakultet, Split

Autor s matičnim brojem:
Igor Rudan, (215633)

Citiraj ovu publikaciju

Surakka, I.; Isaacs, A.; Karssen, L.C.; Rudan, Igor; ...; Ripatti, S.
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol // Plos genetics, 7 (2011), 1002333-1 (međunarodna recenzija, članak, znanstveni)
Surakka, I., Isaacs, A., Karssen, L., Rudan, I., ... & Ripatti, S. (2011) A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol. Plos genetics, 7, 1002333-1.
@article{article, year = {2011}, pages = {1002333-1-1002333}, keywords = {gene, wiast-to-hip}, journal = {Plos genetics}, volume = {7}, issn = {1553-7390}, title = {A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol}, keyword = {gene, wiast-to-hip} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE