Alpha-1-antitrypsin deficiency : from detection to therapy (CROSBI ID 89626)
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Podaci o odgovornosti
Dodig, Slavica ; Čepelak, Ivana ; Raos, Miljenko
engleski
Alpha-1-antitrypsin deficiency : from detection to therapy
Inherited deficiency of alpha-1-antitrypsin is one of the best know abnormalities affecting the lungs. DNA sequence of the responsible gene has been identified, and the gene has been cloned. Genetically engineered alpha-1-antitrypsin has been synthesised and treatment with synthetic protein has been initiated. Many questions remain. The future will clear out the pathogenesis of liver diseases, replaceable, prophylactic and inhalant therapy for specific and nonspecific protection of lung. Early dection of alpha-1-antitrypsin deficiency as well as drug administration are very important for clinical practice. The patient must be educated about environmental control to avoid or eliminate factors that induce lung diseases.
alpha-1-antitrypsin; lung; disease; liver disease
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