Effects-directed Analysis of Contaminated Sediments from the Sava River, Croatia (CROSBI ID 579643)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Ahel, Marijan ; Terzić, Senka ; Lončar, Jovica ; Mikac, Iva ; Žaja, Roko ; Senta, Ivan ; Popović, Marta ; Sauerborn Klobučar, Roberta ; Tollefsen, Knut-Erik ; Thomas, Kevin V ; Smital, Tvrtko
engleski
Effects-directed Analysis of Contaminated Sediments from the Sava River, Croatia
The application of toxicity identification and evaluation (TIE) protocols for the toxicological characterisation of contaminated sediments showed that the majority of the observed adverse ecological effects were associated with toxic organic chemicals. Considering enormous number as well as chemical and toxicological diversity of organic contaminants, effects-directed analysis (EDA) represents the best available tool for the comprehensive assessment of hazardous chemical contamination in aquatic sediments. The aim of this paper is to present the results obtained in a case study carried out in the Sava River basin, Croatia. The analytical approach used for screening included a detailed characterisation of the collected samples, based on the combination of gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/time-of-flight mass spectrometry (LC/Q-TOF). Ecotoxicity profiling of the investigated samples was performed using a battery of bioassays, including cytotoxicity, chronic toxicity, EROD activity ; inhibition of the multixenobiotic resistance (MXR), genotoxicicity and estrogenic potential. The most pronounced effect, detected in the Sava River sediment, was CYP1A induction potential. It was predominately associated with the nonpolar fraction and polycyclic aromatic hydrocarbons were indicated to be responsible for the observed effect. However, other endpoints, such as algal toxicity and estrogenic potential, indicated comparatively higher importance of polar contaminants.
organic contaminants ; effects-directed analysis ; Sava River ; sediment
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
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Podaci o prilogu
31-31.
2011.
objavljeno
Podaci o matičnoj publikaciji
Ecosystem Protection in a Sustainable World: A Challenge for Science and Regulation
Milano: Society of Environmental Toxicology and Chemistry (SETAC), Europe Office
Podaci o skupu
SETAC Europe 21st Annual Meeting Ecosystem Protection in a Sustainable World: A Challenge for Science and Regulation
predavanje
15.05.2011-19.05.2011
Milano, Italija