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Assessing the clinical significance of tumor markers in common neoplasms


Beketić-Orešković, Lidija; Marić, Petra; Ozretić, Petar; Orešković, Darko; Ajduković, Mia; Levanat, Sonja
Assessing the clinical significance of tumor markers in common neoplasms // Frontiers in Bioscience- Elite edition, 4 (2012), 7; 2558-2578 doi:10.2741/566 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Assessing the clinical significance of tumor markers in common neoplasms

Autori
Beketić-Orešković, Lidija ; Marić, Petra ; Ozretić, Petar ; Orešković, Darko ; Ajduković, Mia ; Levanat, Sonja

Izvornik
Frontiers in Bioscience- Elite edition (1093-9946) 4 (2012), 7; 2558-2578

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Tumor markers; neoplasm; clinical significance; breast tumor markers; gastrointestinal tumor markers; gynecological tumor markers; prostate tumor markers; genetic markers; review

Sažetak
The term tumor markers include a spectrum of molecules and substances with widely divergent characteristics whose presence in the significant amount can be related to the malignant disease. An ideal tumor marker should have high specificity and sensitivity, which would allow its use in early diagnosis and prognosis of malignant disease, as well as in prediction of therapeutic response and follow-up of the patients. Numerous biochemical entities have emerged as potentially valuable tumor markers so far, but only few markers showed to be of considerable clinical reliability and have been accepted into standard clinical practice. Recent development of genomics and proteomics has enabled the examination of many new potential tumor markers. Scientific studies on discovery, development, and application of tumor markers have been proceeding quite rapidly providing great opportunities for improving the management of cancer patients. This review is focusing on the clinical usefulness of various tumor markers already in clinical practice as well as certain potential markers, giving a brief description of their prognostic and predictive significance in most common malignancies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
074-0982464-1187 - KLINIČKO ZNAČENJE TUMORSKE HIPOKSIJE U BOLESNIKA LIJEČENIH RADIOTERAPIJOM (Lidija Beketić-Orešković, )
098-0982464-2461 - Prijenos signala u tumorima: Hh-Gli put, interakcije i potencijalne terapije (Sonja Levanat, )

Ustanove
Klinika za tumore,
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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