Napredna pretraga

Pregled bibliografske jedinice broj: 542666

Adamantane-substituted Guanylhydrazones : Novel Inhibitors of Butyrylcholinesterase


Šekutor, Marina; Mlinarić-Majerski, Kata; Hrenar, Tomica; Tomić-Pisarović, Srđanka; Primožič, Ines
Adamantane-substituted Guanylhydrazones : Novel Inhibitors of Butyrylcholinesterase // Bioorganic chemistry, 41-42 (2012), 28-34 doi:10.1016/j.bioorg.2012.01.004 (međunarodna recenzija, članak, znanstveni)


Naslov
Adamantane-substituted Guanylhydrazones : Novel Inhibitors of Butyrylcholinesterase

Autori
Šekutor, Marina ; Mlinarić-Majerski, Kata ; Hrenar, Tomica ; Tomić-Pisarović, Srđanka ; Primožič, Ines

Izvornik
Bioorganic chemistry (0045-2068) 41-42 (2012); 28-34

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Adamantane-substituted guanylhydrazones ; inhibitors ; butyrylcholinesterase ; kinetic and docking studies

Sažetak
A series of novel adamantane-substituted guanylhydrazones was synthesized and used in a study of inhibitory potential toward butyrylcholinesterase. The inhibition constants were determined and docking studies performed to examine the behavior of the inhibitors within the active site regions of the enzyme. The strongest interaction observed in complexes obtained by docking studies were numerous H-bonds of the guanidine group.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982933-2911 - Kavezasti spojevi: ugradbene jedinice u molekularnim sustavima (Kata Majerski, )
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati