engleski

Adamantane-substituted Guanylhydrazones : Novel Inhibitors of Butyrylcholinesterase

A series of novel adamantane-substituted guanylhydrazones was synthesized and used in a study of inhibitory potential toward butyrylcholinesterase. The inhibition constants were determined and docking studies performed to examine the behavior of the inhibitors within the active site regions of the enzyme. The strongest interaction observed in complexes obtained by docking studies were numerous H-bonds of the guanidine group.

adamantane-substituted guanylhydrazones ; inhibitors ; butyrylcholinesterase ; kinetic and docking studies

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