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Pregled bibliografske jedinice broj: 542544

Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid


Jelaković, Bojan; Karanović, Sandra; Vuković-Lela, Ivana; Miller, Frederick; Edwards, Karen; Nikolić, Jovan; Tomić, Karla; Slade, Neda; Brdar, Branko; Turesky, Robert et al.
Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid // KIDNEY INTERNATIONAL, 81 (2012), 6; 559-567 doi:10.1038/ki.2011.371 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 542544 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid

Autori
Jelaković, Bojan ; Karanović, Sandra ; Vuković-Lela, Ivana ; Miller, Frederick ; Edwards, Karen ; Nikolić, Jovan ; Tomić, Karla ; Slade, Neda ; Brdar, Branko ; Turesky, Robert ; Stipančić, Želimir ; Dittrich, Damir ; Grollman Arthur ; Dickman, Kathleen

Izvornik
KIDNEY INTERNATIONAL (0085-2538) 81 (2012), 6; 559-567

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Aristolactam-DNA; biomarker; aristolochic acid

Sažetak
Endemic (Balkan) nephropathy is a chronic tubulointerstitial disease frequently accompanied by urothelial cell carcinomas of the upper urinary tract. This disorder has recently been linked to exposure to aristolochic acid, a powerful nephrotoxin and human carcinogen. Following metabolic activation, aristolochic acid reacts with genomic DNA to form aristolactam-DNA adducts that generate a unique TP53 mutational spectrum in the urothelium. The aristolactam-DNA adducts are concentrated in the renal cortex, thus serving as biomarkers of internal exposure to aristolochic acid. Here, we present molecular epidemiologic evidence relating carcinomas of the upper urinary tract to dietary exposure to aristolochic acid. DNA was extracted from the renal cortex and urothelial tumor tissue of 67 patients that underwent nephroureterectomy for carcinomas of the upper urinary tract and resided in regions of known endemic nephropathy. Ten patients from nonendemic regions with carcinomas of the upper urinary tract served as controls. Aristolactam-DNA adducts were quantified by (32)P-postlabeling, the adduct was confirmed by mass spectrometry, and TP53 mutations in tumor tissues were identified by chip sequencing. Adducts were present in 70% of the endemic cohort and in 94% of patients with specific A:T to T:A mutations in TP53. In contrast, neither aristolactam-DNA adducts nor specific mutations were detected in tissues of patients residing in nonendemic regions. Thus, in genetically susceptible individuals, dietary exposure to aristolochic acid is causally related to endemic nephropathy and carcinomas of the upper urinary tract.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-2391 - Uloga mreže proteina p53/p73 u sarkomima mekih tkiva čovjeka (Slade, Neda, MZOS ) ( POIROT)
108-0000000-0329 - ENDEMSKA NEFROPATIJA U HRVATSKOJ, epidemiologija, dijagnostika i etiopatogeneza (Jelaković, Bojan, MZOS ) ( POIROT)
184-0000000-3459 - Primjena načela medicine osnovane na znanstvenim spoznajama u općoj bolnici (Đanić, Davorin, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
KBC Split,
Opća bolnica "Dr. Josip Benčević"

Citiraj ovu publikaciju

Jelaković, Bojan; Karanović, Sandra; Vuković-Lela, Ivana; Miller, Frederick; Edwards, Karen; Nikolić, Jovan; Tomić, Karla; Slade, Neda; Brdar, Branko; Turesky, Robert et al.
Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid // KIDNEY INTERNATIONAL, 81 (2012), 6; 559-567 doi:10.1038/ki.2011.371 (međunarodna recenzija, članak, znanstveni)
Jelaković, B., Karanović, S., Vuković-Lela, I., Miller, F., Edwards, K., Nikolić, J., Tomić, K., Slade, N., Brdar, B. & Turesky, R. (2012) Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid. KIDNEY INTERNATIONAL, 81 (6), 559-567 doi:10.1038/ki.2011.371.
@article{article, year = {2012}, pages = {559-567}, DOI = {10.1038/ki.2011.371}, keywords = {Aristolactam-DNA, biomarker, aristolochic acid}, journal = {KIDNEY INTERNATIONAL}, doi = {10.1038/ki.2011.371}, volume = {81}, number = {6}, issn = {0085-2538}, title = {Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid}, keyword = {Aristolactam-DNA, biomarker, aristolochic acid} }
@article{article, year = {2012}, pages = {559-567}, DOI = {10.1038/ki.2011.371}, keywords = {Aristolactam-DNA, biomarker, aristolochic acid}, journal = {KIDNEY INTERNATIONAL}, doi = {10.1038/ki.2011.371}, volume = {81}, number = {6}, issn = {0085-2538}, title = {Aristolactam-DNA adducts are a biomarker of environmental exposure to aristolochic acid}, keyword = {Aristolactam-DNA, biomarker, aristolochic acid} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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