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Pregled bibliografske jedinice broj: 542311

A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice


Casós, Kelly; Zaragozá, María C.; Žarković, Neven; Žarković, Kamelija; Andrišić, Luka; Portero-Otín, Manuel; Cacabelo, Daniel; Mitjavil, María T.
A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice // Free radical research, 44 (2010), 7; 821-829 doi:10.3109/10715762.2010.485992 (međunarodna recenzija, članak, znanstveni)


Naslov
A fish oil-rich diet reduces vascular oxidative stress in apoE–/– mice

Autori
Casós, Kelly ; Zaragozá, María C. ; Žarković, Neven ; Žarković, Kamelija ; Andrišić, Luka ; Portero-Otín, Manuel ; Cacabelo, Daniel ; Mitjavil, María T.

Izvornik
Free radical research (1071-5762) 44 (2010), 7; 821-829

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Atherosclerosis; 4-hydroxynonenal; polyunsaturated fatty acids; nitric oxide; superoxide anion; aortic root

Sažetak
Oxidative stress contributes to lipid peroxidation and decreases nitric oxide (NO) bioavailability in atherosclerosis. While long-chain (n-3) polyunsaturated fatty acids (PUFA) are easily oxidized in vitro, they improve endothelial function. Hence, this study postulates that long-chain (n-3) PUFA decrease atherogenic oxidative stress in vivo. To test this, apoE–/– mice were fed a corn oil- or a fish oil (FO)-rich diet for 8, 14 or 20 weeks and parameters related to NO and superoxide (O2.–) plus markers of lipid peroxidation and protein oxidative damage in the aortic root were evaluated. The FO-rich diet increased NO production and endothelial NO synthase (NOS) expression and lowered inducible NOS, p22phox expression and O2.–production after 14 and 20 weeks of diet. Protein lipoxidative damage (including 4-hydroxynonenal) was decreased after a long-term FO-diet. This supports the hypothesis that a FO-rich diet could counteract atherogenic oxidative stress, showing beneficial effects of long-chain (n-3) PUFA.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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