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Inflammatory and neuroprotective proteins in the thalamus following traumatic brain injury in the rat (CROSBI ID 579249)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Pilipović, Kristina ; Župan, Željko ; Župan, Gordana Inflammatory and neuroprotective proteins in the thalamus following traumatic brain injury in the rat // Book of Abstracts / Osredkar, D. ; Koritnik, B. ; Pelko, M. (ur.). Ljubljana: Neuroscience Association, 2011. str. 142-142

Podaci o odgovornosti

Pilipović, Kristina ; Župan, Željko ; Župan, Gordana

engleski

Inflammatory and neuroprotective proteins in the thalamus following traumatic brain injury in the rat

Thalamus is the brain region whose damage has been well documented after both human and experimental traumatic brain injury (TBI). Molecular mechanisms which lead to posttraumatic cell death or support the neuronal survival in the thalamus, in this entity, have not yet been fully characterized. Therefore, aim of this study was to determine the changes in several markers of inflammation and also cell protection following experimental TBI in the rat. Experiments were carried out on adult male rats. TBI of moderate severity was performed over the left parietal cortex using the lateral fiuid percussion brain injury model. Sham-operated animals were used as the control group. Rats were sacrificed 24 h after the TBI induction and the thalami were processed for the Western blot analyses of different protein expressions. TBI caused significant increases of the cyclooxygenase-2, inducible nitric oxide synthase and heat shock protein 70 expressions in the thalamus of rats with TBI in relation to the values registered in sham-operated animals. Thalamic expressions of inhibitory kappa B alpha and brain derived neurotrophic factor were unaffected by TBI in our experimental conditions.

traumatic brain injury; thalamus; inflammation; neuroprotection; rat

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Podaci o prilogu

142-142.

2011.

objavljeno

Podaci o matičnoj publikaciji

Book of Abstracts

Osredkar, D. ; Koritnik, B. ; Pelko, M.

Ljubljana: Neuroscience Association

978-961-91704-4-1

Podaci o skupu

SiNAPSA Neuroscience Conference ´11

poster

22.09.2011-25.09.2011

Ljubljana, Slovenija

Povezanost rada

nije evidentirano