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Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines (CROSBI ID 176900)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Cvjetko, Marina ; Radošević, Kristina ; Tomica, Andrej ; Slivac, Igor ; Vorkapić-Furač, Jasna ; Gaurina Srček, Višnja Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines // Arhiv za higijenu rada i toksikologiju, 63 (2012), 1; 15-19. doi: 10.2478/10004-1254-63-2012-2132

Podaci o odgovornosti

Cvjetko, Marina ; Radošević, Kristina ; Tomica, Andrej ; Slivac, Igor ; Vorkapić-Furač, Jasna ; Gaurina Srček, Višnja

engleski

Cytotoxic Effects of Imidazolium Ionic Liquids on Fish and Human Cell Lines

Ionic liquids bring a promise of a wide range of "green" applications that could replace conventional volatile solvents. However, before these applications become large-scale, their toxicity needs to be investigated in order to predict the impact on human health and environment. In this study we assessed the cytotoxicity of imidazolium ionic liquids (in the concentrations between 0.1 mmol L-1 and 10 mmol L-1) in the ovarian fish cell line CCO and the human tumour cell line HeLa using the MTT cell viability assay. Our results showed that the most cytotoxic ionic liquid was 1-n-butyl-3-methylimidazolium bis(trifluoromethylsulphonyl)imide, [BMIM][Tf2N], followed by 1-n-butyl-3-methylimidazolium tetrafluoroborate [BMIM][BF4], 1-n-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6], and 1, 3-dimethylimidazolium hexafluorophosphate [MMIM][PF6]. Generally, the effects were concentration-dependent. They also depended on the type of anion and the n-alkyl chain length. The comparison between the fish CCO and human HeLa cell lines suggests that CCO cells provide a good biological system for initial toxicity testing of ionic liquids that could replace in vivo bioassays.

CCO cells; HeLa cells; imidazolium ionic liquids; MTT assay

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Podaci o izdanju

63 (1)

2012.

15-19

objavljeno

0004-1254

10.2478/10004-1254-63-2012-2132

Povezanost rada

Biotehnologija

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